SARS-CoV-2 parental vaccination and risk of multisystem inflammatory syndrome in children: a single-center retrospective study.

IF 2.1 Q4 IMMUNOLOGY

Clinical and Experimental Vaccine Research Pub Date : 2024-07-01 Epub Date: 2024-07-31 DOI:10.7774/cevr.2024.13.3.225

Raffaele Falsaperla, Vincenzo Sortino, Ausilia Desiree Collotta, Patrizia Grassi, Marco Simone Vaccalluzzo, Alfredo Pulvirenti, Francesco Gambilonghi, Martino Ruggieri

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引用次数: 0

Abstract

Purpose: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) usually causes a mild disease in children and the most serious consequence is multisystem inflammatory syndrome in children (MIS-C). Currently, there are no data about the protective role of vaccination performed by parents on children regarding the development of MIS-C. The aim of our study is to establish whether parental vaccination is related to MIS-C and the protective value of SARS-CoV-2 vaccination performed by parents against the occurrence of MIS-C in their children.

Materials and methods: Our retrospective single center study included 124 patients aged 1 month to 18 years admitted to emergency department from April 2020 to March 2022 for coronavirus disease 2019 disease.

Results: Parental vaccination was negatively correlated with the development of MIS-C: 4% of patients with both parents vaccinated developed MIS-C, while patients with no parent vaccinated to have developed MIS-C were 20%.

Conclusion: Parental vaccination could be an important factor influencing the course of the disease and reduces the probability that a child would develop MIS-C by 83% if both parents vaccinated.

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父母接种 SARS-CoV-2 疫苗与儿童患多系统炎症综合征的风险：一项单中心回顾性研究。

目的：严重急性呼吸系统综合征冠状病毒 2（SARS-CoV-2）通常会导致儿童轻微发病，最严重的后果是儿童多系统炎症综合征（MIS-C）。目前，还没有数据表明父母为儿童接种疫苗对 MIS-C 的发生有保护作用。我们的研究旨在确定父母接种疫苗是否与 MIS-C 有关，以及父母接种 SARS-CoV-2 疫苗对其子女发生 MIS-C 的保护作用：我们的回顾性单中心研究纳入了2020年4月至2022年3月期间因冠状病毒病2019年送彩金网站大全急诊科收治的124名1个月至18岁的患者：父母接种疫苗与MIS-C的发生呈负相关：父母均接种疫苗的患者中有4%发生MIS-C，而父母均未接种疫苗的患者中有20%发生MIS-C：结论：父母接种疫苗可能是影响疾病进程的一个重要因素，如果父母双方都接种了疫苗，儿童患 MIS-C 的概率会降低 83%。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical and Experimental Vaccine Research IMMUNOLOGY-

CiteScore

3.70

自引率

3.70%

发文量

审稿时长

8 weeks

期刊介绍： Clin Exp Vaccine Res, the official English journal of the Korean Vaccine Society, is an international, peer reviewed, and open-access journal. It covers all areas related to vaccines and vaccination. Clin Exp Vaccine Res publishes editorials, review articles, special articles, original articles, case reports, brief communications, and correspondences covering a wide range of clinical and experimental subjects including vaccines and vaccination for human and animals against infectious diseases caused by viruses, bacteria, parasites and tumor. The scope of the journal is to disseminate information that may contribute to elaborate vaccine development and vaccination strategies targeting infectious diseases and tumors in human and animals. Relevant topics range from experimental approaches to (pre)clinical trials for the vaccine research based on, but not limited to, basic laboratory, translational, and (pre)clinical investigations, epidemiology of infectious diseases and progression of all aspects in the health related issues. It is published printed and open accessed online issues (https://ecevr.org) two times per year in 31 January and 31 July. Clin Exp Vaccine Res is linked to many international databases and is made freely available to institutions and individuals worldwide