Risk factors for long COVID syndrome in postmenopausal women with previously reported diagnosis of COVID-19

IF 4.3 3区材料科学 Q1 ENGINEERING, ELECTRICAL & ELECTRONIC

ACS Applied Electronic Materials Pub Date : 2024-08-12 DOI:10.1016/j.annepidem.2024.08.003

Marian L. Neuhouser , Hamza Islam Butt , Chengcheng Hu , Aladdin H. Shadyab , Lorena Garcia , Shawna Follis , Charles Mouton , Holly R. Harris , Jean Wactawski-Wende , Emily W. Gower , Mara Vitolins , Diane Von Ah , Rami Nassir , Shama Karanth , Ted Ng , Electra Paskett , JoAnn E. Manson , Zhao Chen

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引用次数: 0

Abstract

Purpose

Long COVID-19 syndrome occurs in 10–20 % of people after a confirmed/probable SARS-COV-2 infection; new symptoms begin within three months of COVID-19 diagnosis and last > 8 weeks. Little is known about risk factors for long COVID, particularly in older people who are at greater risk of COVID complications.

Methods

Data are from Women’s Health Initiative (WHI) postmenopausal women who completed COVID surveys that included questions on whether they had ever been diagnosed with COVID and length and nature of symptoms. Long COVID was classified using standard consensus criteria. Using WHI demographic and health data collected at study enrollment (1993–98) through the present day, machine learning identified the top 20 risk factors for long COVID. These variables were tested in logistic regression models.

Results

Of n = 37,280 survey respondents, 1237 (mean age = 83 years) reported a positive COVID-19 test and 425 (30 %) reported long COVID. Symptoms included an array of neurological, cardio-pulmonary, musculoskeletal, and general fatigue, and malaise symptoms. Long COVID risk factors included weight loss, physical and mobility limitations, and specific heath conditions (e.g., history of heart valve procedure, rheumatoid arthritis).

Conclusions

Knowledge of risk factors for long COVID may be the first step in understanding the etiology of this complex disease.

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先前报告诊断为 COVID-19 的绝经后妇女患长 COVID 综合征的风险因素。

目的：在确诊/可能感染 SARS-COV-2 后，10%-20% 的人会出现长 COVID-19 综合征；在确诊 COVID-19 后三个月内开始出现新症状，并持续 8 周以上。人们对引起长期 COVID 的危险因素知之甚少，尤其是老年人，他们发生 COVID 并发症的风险更大：数据来自妇女健康倡议（WHI）的绝经后妇女，她们完成了 COVID 调查，其中包括是否曾被诊断为 COVID 以及症状持续时间和性质等问题。长 COVID 采用标准的共识标准进行分类。利用从研究注册（1993-1998 年）至今收集到的 WHI 人口统计学和健康数据，机器学习确定了长 COVID 的前 20 个风险因素。这些变量在逻辑回归模型中进行了测试：在 37,280 名调查对象中，1,237 人（平均年龄 = 83 岁）报告 COVID-19 检测呈阳性，425 人（30%）报告长期 COVID。症状包括一系列神经、心肺、肌肉骨骼、全身疲劳和不适症状。长期 COVID 的风险因素包括体重减轻、身体和行动受限以及特定的健康状况（如心脏瓣膜手术史、类风湿性关节炎）：结论：了解长COVID的风险因素可能是了解这种复杂疾病病因的第一步。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ACS Applied Electronic Materials Multiple-

CiteScore

7.20

自引率

4.30%

发文量

567