Nontraditional Lipid Parameters as a Predictor of Cardiovascular Disease Risk in Nepalese Women.

IF 1.2 Q3 OBSTETRICS & GYNECOLOGY
Journal of Mid-life Health Pub Date : 2024-04-01 Epub Date: 2024-07-05 DOI:10.4103/jmh.jmh_179_23
Jasper Adhikaree, Ruyusha Shrestha, Prabina Bomjan, Shreya Pokharel, Ashmita Shrestha, Anusha Siwakoti, Rashila Acharya, Roy Rillera Marzo, Swosti Acharya, Ritesh Pokhrel, Prachand Man Singh Rajbhandari
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引用次数: 0

Abstract

Background: The use of nontraditional lipid parameters for assessing clinical conditions is emerging; however, no study has identified thresholds for those parameters for the identification of cardiovascular disease (CVD) risk. The present study aimed to establish the thresholds of nontraditional lipid parameters and test its ability to identify CVD risk factors.

Methodology: A cross-sectional study in women (n = 369, age: 46 ± 13 years, body mass index (BMI): 26.31 ± 2.54 kg/m2) was conducted. Blood samples were collected and high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol, total cholesterol (TC), and triglycerides (TGs) were estimated. Subsequently, nontraditional lipid parameters were calculated, namely non-HDL-C, Castelli's Risk Index II (CRI-II), CRI-I, lipoprotein combined index (LCI), atherogenic index (AI), and AI of plasma (AIP).

Results: Based on TC (≥200 mg/dL), the derived thresholds for non-HDL-C, CRI-II, CRI-I, LCI, AI, and AIP were 139 mg/dL, 2.29, 3.689, 58,066, 2.687, and 0.487, respectively. Similarly, based on the threshold of TG (≥150 mg/dL), the derived thresholds for non-HDL-C, CRI-II, CRI-I, LCI, AI, and AIP were 127 mg/dL, 2.3, 3.959, 58,251, 2.959, and 0.467, respectively. Out of considered five risk factors, non-HDL-C, CRI-II, CRI-I, LCI, and AI thresholds were capable in identifying four risk factors (physical activity, blood pressure, BMI, and age) and AIP was able to associate with two risk factors at most (blood pressure and BMI).

Conclusion: The derived thresholds of nontraditional lipid parameters were capable of differentiating between CVD risk and nonrisk groups suggesting the possible use of these thresholds for studying CVD risk.

作为尼泊尔妇女心血管疾病风险预测指标的非传统血脂参数。
背景:使用非传统血脂参数评估临床状况的做法正在兴起;然而,还没有研究确定这些参数用于识别心血管疾病(CVD)风险的阈值。本研究旨在确定非传统血脂参数的阈值,并测试其识别心血管疾病风险因素的能力:对女性(n = 369,年龄:46 ± 13 岁,体重指数(BMI):26.31 ± 2.54 kg/m2)进行横断面研究。研究人员采集了血液样本,并估算了高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇、总胆固醇(TC)和甘油三酯(TGs)。随后计算了非传统血脂参数,即非高密度脂蛋白胆固醇、卡斯泰利风险指数 II(CRI-II)、CRI-I、脂蛋白综合指数(LCI)、致动脉粥样硬化指数(AI)和血浆AI(AIP):根据血清总胆固醇(≥200 毫克/分升),非高密度脂蛋白胆固醇、CRI-II、CRI-I、LCI、AI 和 AIP 的阈值分别为 139 毫克/分升、2.29、3.689、58,066、2.687 和 0.487。同样,根据总胆固醇的阈值(≥150 毫克/分升),非高密度脂蛋白胆固醇、CRI-II、CRI-I、LCI、AI 和 AIP 的阈值分别为 127 毫克/分升、2.3、3.959、58 251、2.959 和 0.467。在考虑的五个风险因素中,非高密度脂蛋白胆固醇、CRI-II、CRI-I、LCI 和 AI 临界值能够识别四个风险因素(体力活动、血压、体重指数和年龄),而 AIP 最多能够与两个风险因素(血压和体重指数)相关联:结论:得出的非传统血脂参数阈值能够区分心血管疾病风险组和非风险组,这表明这些阈值可用于研究心血管疾病风险。
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来源期刊
Journal of Mid-life Health
Journal of Mid-life Health Social Sciences-Health (social science)
CiteScore
1.70
自引率
9.10%
发文量
39
审稿时长
43 weeks
期刊介绍: Journal of mid-life health is the official journal of the Indian Menopause society published Quarterly in January, April, July and October. It is peer reviewed, scientific journal of mid-life health and its problems. It includes all aspects of mid-life health, preventive as well as curative. The journal publishes on subjects such as gynecology, neurology, geriatrics, psychiatry, endocrinology, urology, andrology, psychology, healthy ageing, cardiovascular health, bone health, quality of life etc. as relevant of men and women in their midlife. The Journal provides a visible platform to the researchers as well as clinicians to publish their experiences in this area thereby helping in the promotion of mid-life health leading to healthy ageing, growing need due to increasing life expectancy. The Editorial team has maintained high standards and published original research papers, case reports and review articles from the best of the best contributors both national & international, consistently so that now, it has become a great tool in the hands of menopause practitioners.
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