Evaluation of Hyponatremia in Infants on Vasopressin Therapy.

Q2 Medicine
Caitlin Hawkins, Brianna Hemmann, Trina Hemmelgarn
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引用次数: 0

Abstract

Objective: Vasopressin has systemic vasoconstrictive yet pulmonary vasodilatory effects, making it an ideal agent for hypotension management in infants with congenital diaphragmatic hernia (CDH)-associated pulmonary hypertension. The side effects of vasopressin in this population, such as hyponatremia, are understudied. This study aims to characterize the effect of vasopressin on sodium concentrations in infants with and without CDH.

Methods: This was a retrospective review of patients who received vasopressin while admitted to a level IV neonatal intensive care unit. The primary outcome was the incidence of hyponatremia (blood sodium <135 mmol/L) during vasopressin therapy. Secondary outcomes included time to hyponatremia, dose and duration of vasopressin, incidence of severe hyponatremia (blood sodium <125 mmol/L), and hypertonic saline use. Both blood serum and blood gas sample sodium concentrations were used to compare CDH vs non-CDH patients.

Results: The average difference between baseline and lowest blood sodium was significant for both CDH and non-CDH patients for all samples (p < 0.001). There was no significant difference in the primary outcome, nor in the secondary outcomes of time to hyponatremia or duration of vasopressin infusion. The average dose of vasopressin was higher in the CDH vs non-CDH group (p = 0.018). The incidences of severe hyponatremia and hypertonic saline use were greater in the CDH vs non-CDH group for patients who had blood serum sodium samples collected (p = 0.049 and p = 0.033, respectively).

Conclusions: This study showed that severe hyponatremia occurred more frequently in CDH vs non-CDH patients. Extreme caution is necessary when managing total body sodium in patients with CDH.

评估接受血管加压素治疗的婴儿的低钠血症。
目的:血管加压素具有全身血管收缩和肺血管扩张的作用,是治疗先天性膈疝(CDH)相关性肺动脉高压婴儿低血压的理想药物。目前对血管加压素在这类人群中的副作用(如低钠血症)研究不足。本研究旨在描述血管加压素对患有和未患有 CDH 的婴儿钠浓度的影响:本研究对入住四级新生儿重症监护病房并接受血管加压素治疗的患者进行了回顾性研究。主要结果是低钠血症的发生率(血钠结果):在所有样本中,CDH 和非 CDH 患者的基线血钠与最低血钠之间的平均差异显著(p < 0.001)。在主要结果和次要结果(低钠血症发生时间或输注血管加压素的持续时间)方面均无明显差异。CDH 组与非 CDH 组相比,血管加压素的平均剂量更高(p = 0.018)。采集血清钠样本的 CDH 组与非 CDH 组患者中,严重低钠血症和使用高渗盐水的发生率更高(分别为 p = 0.049 和 p = 0.033):本研究表明,CDH 与非 CDH 患者发生严重低钠血症的频率更高。在管理 CDH 患者体内总钠时必须格外谨慎。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Journal of Pediatric Pharmacology and Therapeutics
Journal of Pediatric Pharmacology and Therapeutics Medicine-Pediatrics, Perinatology and Child Health
CiteScore
2.40
自引率
0.00%
发文量
90
期刊介绍: The Journal of Pediatric Pharmacology and Therapeutics is the official journal of the Pediatric Pharmacy Advocacy Group. JPPT is a peer-reviewed multi disciplinary journal that is devoted to promoting the safe and effective use of medications in infants and children. To this end, the journal publishes practical information for all practitioners who provide care to pediatric patients. Each issue includes review articles, original clinical investigations, case reports, editorials, and other information relevant to pediatric medication therapy. The Journal focuses all work on issues related to the practice of pediatric pharmacology and therapeutics. The scope of content includes pharmacotherapy, extemporaneous compounding, dosing, methods of medication administration, medication error prevention, and legislative issues. The Journal will contain original research, review articles, short subjects, case reports, clinical investigations, editorials, and news from such organizations as the Pediatric Pharmacy Advocacy Group, the FDA, the American Academy of Pediatrics, the American Society of Health-System Pharmacists, and so on.
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