Impact of historical disease conditions on mortality and life expectancy in patients with advanced schistosomiasis in Hunan Province, China.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-08-15 DOI:10.1093/trstmh/trae052

Honglin Jiang, Jie Zhou, Xinting Cai, Benjiao Hu, Huilan Wang, Chen Fu, Ning Xu, Yanfeng Gong, Yixin Tong, Jiangfan Yin, Junhui Huang, Jiamin Wang, Qingwu Jiang, Songyue Liang, Yibiao Zhou

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引用次数: 0

Abstract

Background: Although the prognosis of advanced schistosomiasis patients has significantly improved, the impact of historical disease conditions on life expectancy remains unclear.

Methods: Utilizing data from an advanced schistosomiasis cohort (n=10 362) from 2008 to 2019 in Hunan, China, we examined five historical disease conditions: times of praziquantel treatment, the history of ascites, splenectomy, upper gastrointestinal bleeding (UGIB) and hepatic coma. Using latent class analysis, participants were categorized into three groups: Group 1 (characterized by no risk conditions), Group 2 (had ≤3 times of praziquantel treatment without UGIB history) and Group 3 (had UGIB history). Life expectancies were calculated using the life table method.

Results: At the age of 45 y, patients with ≤3 times of praziquantel treatment, a history of ascites, UGIB, hepatic coma and those without splenectomy exhibited lower life expectancies. Groups 1, 2 and 3 had estimated life expectancies of 32.32, 26.76 and 25.38 y, respectively. Compared with Group 1, women in Group 3 experienced greater life expectancy loss than those in Group 2, with the difference narrowing with age.

Conclusions: Based on the consideration of overall physical conditions, tailored treatment and healthcare, along with public health interventions targeting diverse populations, could mitigate the prevalence of poor disease conditions and premature deaths.

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历史疾病状况对中国湖南省晚期血吸虫病患者死亡率和预期寿命的影响。

背景：尽管晚期血吸虫病患者的预后已明显改善，但历史疾病状况对预期寿命的影响仍不明确：尽管晚期血吸虫病患者的预后已明显改善，但历史疾病状况对预期寿命的影响仍不清楚：利用中国湖南2008年至2019年的晚期血吸虫病队列数据（n=10 362），我们研究了五种历史疾病情况：吡喹酮治疗时间、腹水病史、脾切除术、上消化道出血（UGIB）和肝昏迷。通过潜类分析，参与者被分为三组：第 1 组（无风险情况）、第 2 组（吡喹酮治疗次数≤3 次，无 UGIB 病史）和第 3 组（有 UGIB 病史）。采用生命表法计算预期寿命：结果：45岁时，吡喹酮治疗次数≤3次、有腹水、UGIB、肝昏迷病史和未做脾脏切除术的患者预期寿命较短。第 1、2 和 3 组的预期寿命分别为 32.32、26.76 和 25.38 岁。与第 1 组相比，第 3 组妇女的预期寿命损失大于第 2 组妇女，随着年龄的增长，差异逐渐缩小：结论：在考虑整体身体状况的基础上，有针对性的治疗和保健，以及针对不同人群的公共卫生干预措施，可减轻疾病状况不佳和过早死亡的发生率。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.