The association between sleep quantity, insomnia and lung cancer risk - A systematic review and meta-analysis.

IF 2.1 4区医学 Q3 CLINICAL NEUROLOGY

Sleep and Breathing Pub Date : 2024-08-15 DOI:10.1007/s11325-024-03092-3

Brian Sheng Yep Yeo, Jin Hean Koh, Bryan Yichong Shi, Jun He Chan, Adele Chin Wei Ng, Shaun Loh, Leong Chai Leow, Thun How Ong, Joshua J Gooley, Song Tar Toh

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Abstract

Purpose: The effect of various sleep traits on the risk of lung cancer differs among pre-existing studies. This study aims to systematically review and synthesise the association between sleep duration and insomnia with the incidence of lung cancer.

Methods: PubMed, Embase and The Cochrane Library were searched from inception to 23 April 2023 for observational studies examining the effect of sleep quantity or insomnia on lung cancer incidence. We pooled maximally-adjusted hazard ratios and odds ratios separately using random effects inverse variance weighted models. The risk of bias of observational studies was assessed using the Newcastle-Ottawa Scale.

Results: We included 11 observational studies with a pooled cohort of 5,049,141 patients. The mean age of the patients was 49.5 ± 17.7 years, and 51.4% were males. The risk of bias ranged from low-moderate. Individuals who slept for a shorter or longer duration than the reference range of sleep per night showed an increased risk of lung cancer by 11% (HR:1.11; 95%CI:1.00-1.23) and 16% (HR:1.16; 95%CI:1.06-1.27) respectively. Furthermore, individuals with insomnia symptoms had a 9% greater risk of lung cancer than those without symptoms (HR:1.09; 95%CI:1.05-1.13).

Conclusion: This study suggests that insufficient sleep, excessive sleep and insomnia may be associated with an increased risk of lung cancer. Physicians should be mindful of this association and encourage healthy sleep practises among patients. Given the observed heterogeneity among some pre-existing studies, future research with longer periods of follow-up, greater control for covariates and objective testing of sleep parameters may add value to this topic.

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睡眠质量、失眠与肺癌风险之间的关系--系统回顾与荟萃分析。

目的：各种睡眠特征对肺癌风险的影响在已有研究中存在差异。本研究旨在系统回顾和总结睡眠时间和失眠与肺癌发病率之间的关系：方法：我们检索了 PubMed、Embase 和 Cochrane 图书馆中从开始到 2023 年 4 月 23 日有关睡眠时间或失眠对肺癌发病率影响的观察性研究。我们使用随机效应反方差加权模型分别汇总了最大调整危险比和几率比。我们使用纽卡斯尔-渥太华量表评估了观察性研究的偏倚风险：我们共纳入了 11 项观察性研究，汇集了 5,049,141 名患者。患者的平均年龄为 49.5 ± 17.7 岁，51.4% 为男性。偏倚风险从低到中等不等。每晚睡眠时间短于或长于参考睡眠时间范围的人患肺癌的风险分别增加了11%（HR:1.11；95%CI:1.00-1.23）和16%（HR:1.16；95%CI:1.06-1.27）。此外，与没有失眠症状的人相比，有失眠症状的人患肺癌的风险要高出9%（HR：1.09；95%CI：1.05-1.13）：这项研究表明，睡眠不足、睡眠过度和失眠可能与肺癌风险增加有关。医生应注意这种关联，并鼓励患者保持健康的睡眠习惯。鉴于已观察到的一些已有研究之间的异质性，今后的研究应进行更长时间的随访，加强对协变量的控制，并对睡眠参数进行客观测试，从而为这一课题增添价值。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Sleep and Breathing 医学-呼吸系统

CiteScore

5.20

自引率

4.00%

发文量

222

审稿时长

3-8 weeks

期刊介绍： The journal Sleep and Breathing aims to reflect the state of the art in the international science and practice of sleep medicine. The journal is based on the recognition that management of sleep disorders requires a multi-disciplinary approach and diverse perspectives. The initial focus of Sleep and Breathing is on timely and original studies that collect, intervene, or otherwise inform all clinicians and scientists in medicine, dentistry and oral surgery, otolaryngology, and epidemiology on the management of the upper airway during sleep. Furthermore, Sleep and Breathing endeavors to bring readers cutting edge information about all evolving aspects of common sleep disorders or disruptions, such as insomnia and shift work. The journal includes not only patient studies, but also studies that emphasize the principles of physiology and pathophysiology or illustrate potentially novel approaches to diagnosis and treatment. In addition, the journal features articles that describe patient-oriented and cost-benefit health outcomes research. Thus, with peer review by an international Editorial Board and prompt English-language publication, Sleep and Breathing provides rapid dissemination of clinical and clinically related scientific information. But it also does more: it is dedicated to making the most important developments in sleep disordered breathing easily accessible to clinicians who are treating sleep apnea by presenting well-chosen, well-written, and highly organized information that is useful for patient care.