Comparison of the Efficacy of Propranolol Versus Valsartan in the Prevention of Migraine: A Randomized Controlled Trial.

IF 1.6 4区医学 Q2 NURSING

Pain Management Nursing Pub Date : 2024-08-13 DOI:10.1016/j.pmn.2024.07.001

Arash Mosarrezaii, Danial Tahazadeh, Hussein Soleimantabar, Pegah Panahi

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引用次数: 0

Abstract

Background: Migraine is a prevalent episodic headache that affects approximately 14%-15% of the global population. Since valsartan is an antihypertensive drug, it is hypothesized that taking valsartan can prevent migraine attacks in patients with the condition. This study aimed to determine the efficacy of propranolol versus valsartan in preventing migraine attacks.

Material and methods: This randomized controlled trial was conducted on 56 patients with migraine from a neurology clinic. Patients were divided into two equal groups of 28 individuals, after providing informed consent. The patients then received either propranolol or valsartan treatment. The intensity and frequency of migraines were compared before and after treatment in both study groups.

Results: The patients' mean age was 32.78 years old (±6.9 SD), and 64% of the patients were female. After a 1-month treatment period, the results showed that valsartan patients experienced significantly fewer severe migraine attacks compared to propranolol patients.

Conclusion: According to the results of the present study, valsartan may be at least as effective as propranolol and perhaps more effective on some measures.

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普萘洛尔与缬沙坦在预防偏头痛方面的疗效比较：随机对照试验

背景：偏头痛是一种常见的发作性头痛，约占全球总人口的 14%-15%。由于缬沙坦是一种降压药，因此假设服用缬沙坦可以预防偏头痛患者的偏头痛发作。本研究旨在确定普萘洛尔与缬沙坦在预防偏头痛发作方面的疗效：这项随机对照试验针对一家神经病学诊所的 56 名偏头痛患者。在获得知情同意后，患者被平均分为两组，每组 28 人。然后，患者接受普萘洛尔或缬沙坦治疗。比较两组患者治疗前后偏头痛的强度和频率：患者的平均年龄为 32.78 岁（±6.9 SD），64% 的患者为女性。经过1个月的治疗，结果显示缬沙坦患者的严重偏头痛发作次数明显少于普萘洛尔患者：结论：根据本研究的结果，缬沙坦至少与普萘洛尔一样有效，而且在某些方面可能更有效。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pain Management Nursing 医学-护理

CiteScore

3.00

自引率

5.90%

发文量

187

审稿时长

>12 weeks

期刊介绍： This peer-reviewed journal offers a unique focus on the realm of pain management as it applies to nursing. Original and review articles from experts in the field offer key insights in the areas of clinical practice, advocacy, education, administration, and research. Additional features include practice guidelines and pharmacology updates.