Chinese visceral adipose index is more closely associated with risk of arterial stiffness than traditional obesity indicators: a cohort study.

IF 3.4 3区医学 Q2 ENDOCRINOLOGY & METABOLISM

Diabetology & Metabolic Syndrome Pub Date : 2024-08-14 DOI:10.1186/s13098-024-01436-3

Huayu Sun, Yan Tian, Hao Wu, Chenrui Zhu, Liming Lin, Shuohua Chen, Shouling Wu, Yuntao Wu

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引用次数: 0

Abstract

Background: The Chinese visceral adiposity index (CVAI) is a new index to evaluate visceral adipose tissue in the Chinese population. Arterial stiffness (AS) is a kind of degeneration of the large arteries, and obesity is an essential contributing factor to AS. Our study aimed to explore the longitudinal association between CVAI and the risk of AS and to compare the predictive power of CVAI, body mass index (BMI), and waist circumference (WC) for AS.

Methods: Between 2010 and 2020, a total of 14,877 participants participating in at least two brachial-ankle pulse wave velocity (baPWV) measurements from the Kailuan study were included. The Cox proportional hazard regression models were performed to evaluate the longitudinal association between CVAI and the risk of AS. The area under the receiver operating characteristic (ROC) curve was calculated to compare the predictive power of CVAI, BMI, and WC for AS.

Results: After adjusting for potential confounding factors, CVAI was significantly associated with the risk of AS. Compared with the first CVAI quartile, the hazard ratios (HR) and 95% CI of the second, third, and fourth quartiles were 1.30 (1.09-1.56), 1.37 (1.15-1.63), and 1.49 (1.24-1.78), respectively. The area under ROC curve of CVAI was 0.661, significantly higher than BMI (AUC: 0.582) and WC (AUC: 0.606).

Conclusion: CVAI may be a reliable indicator to identify high-risk groups of AS in the Chinese general population, and the predictive power of CVAI for AS was better than BMI and WC.

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与传统肥胖指标相比，中国人的内脏脂肪指数与动脉僵化风险的关系更密切：一项队列研究。

背景：中国人内脏脂肪指数（CVAI）是评估中国人内脏脂肪组织的新指标。动脉僵化（AS）是大动脉变性的一种，而肥胖是导致动脉僵化的一个重要因素。我们的研究旨在探讨CVAI与动脉僵化风险之间的纵向关联，并比较CVAI、体重指数（BMI）和腰围（WC）对动脉僵化的预测能力：方法：纳入了 2010 年至 2020 年间参加过至少两次肱踝关节脉搏波速度（baPWV）测量的开滦研究的 14877 名参与者。采用 Cox 比例危险回归模型评估 CVAI 与 AS 风险之间的纵向关联。通过计算接收者操作特征曲线下面积（ROC）来比较CVAI、体重指数和腹围对强直性脊柱炎的预测能力：结果：在调整了潜在的混杂因素后，CVAI 与强直性脊柱炎的风险有显著相关性。与 CVAI 第一四分位数相比，第二、第三和第四四分位数的危险比（HR）和 95% CI 分别为 1.30（1.09-1.56）、1.37（1.15-1.63）和 1.49（1.24-1.78）。CVAI的ROC曲线下面积为0.661，明显高于BMI（AUC：0.582）和WC（AUC：0.606）：结论：CVAI可能是在中国普通人群中识别强直性脊柱炎高危人群的可靠指标，其对强直性脊柱炎的预测能力优于体重指数（BMI）和体重指数（WC）。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Diabetology & Metabolic Syndrome ENDOCRINOLOGY & METABOLISM-

CiteScore

6.20

自引率

0.00%

发文量

170

审稿时长

7.5 months

期刊介绍： Diabetology & Metabolic Syndrome publishes articles on all aspects of the pathophysiology of diabetes and metabolic syndrome. By publishing original material exploring any area of laboratory, animal or clinical research into diabetes and metabolic syndrome, the journal offers a high-visibility forum for new insights and discussions into the issues of importance to the relevant community.