Correlation between Chemical Fertilization Practices, Phytochemical Response, and Biological Activities of Cannabis sativa L.

IF 1.6 4区医学 Q4 BIOCHEMICAL RESEARCH METHODS

Combinatorial chemistry & high throughput screening Pub Date : 2024-08-13 DOI:10.2174/0113862073319590240801112332

Marianela Simonutti, Gisela Seimandi, Geraldina Richard, Juan Marcelo Zabala, Marcos Derita

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Abstract

The plant kingdom offers a wealth of molecules with potential efficacy against various human, animal, and plant crop infections and illnesses. Cannabis sativa L. has garnered significant attention in recent decades within the scientific community due to its broad biological activity. Key bioactive compounds such as cannabinoids and phenolic compounds have been isolated from this plant, driving its bioactivity. Numerous studies have highlighted the impact of different agronomic practices, particularly fertilization, on the phytochemical composition, notably altering the percentage of various chemical groups. This review aims to present updated fertilization recommendations, crop requirements, and their implications for the chemical composition of C. sativa plants, along with major biological properties documented in the literature over the past five years. Various databases were utilized to summarize information on fertilization and crop requirements, chemical composition, bioassays employed, natural products (extracts or isolated compounds), and bioactivity results. Through this review, it is evident that C. sativa holds promise as a source of novel molecules for treating diverse human diseases. Nonetheless, careful consideration of agronomic practices is essential to optimize chemical composition and maximize therapeutic potential.

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大麻化学施肥方法、植物化学反应和生物活性之间的相关性

植物王国提供了大量对人类、动物和植物作物的各种感染和疾病具有潜在疗效的分子。由于大麻具有广泛的生物活性，近几十年来它在科学界引起了极大的关注。从这种植物中分离出了大麻素和酚类化合物等关键生物活性化合物，推动了其生物活性的发展。许多研究都强调了不同农艺方法（尤其是施肥）对植物化学成分的影响，特别是改变了各种化学组的百分比。本综述旨在介绍最新的施肥建议、作物要求及其对荠菜植物化学成分的影响，以及过去五年文献中记载的主要生物特性。我们利用各种数据库总结了有关施肥和作物要求、化学成分、采用的生物测定、天然产品（提取物或分离化合物）以及生物活性结果的信息。通过这篇综述，可以看出荠菜有望成为治疗各种人类疾病的新型分子来源。然而，要优化化学成分并最大限度地发挥治疗潜力，必须仔细考虑农艺实践。

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来源期刊

Combinatorial chemistry & high throughput screening 化学-生化研究方法

CiteScore

3.10

自引率

5.60%

发文量

327

审稿时长

7.5 months

期刊介绍： Combinatorial Chemistry & High Throughput Screening (CCHTS) publishes full length original research articles and reviews/mini-reviews dealing with various topics related to chemical biology (High Throughput Screening, Combinatorial Chemistry, Chemoinformatics, Laboratory Automation and Compound management) in advancing drug discovery research. Original research articles and reviews in the following areas are of special interest to the readers of this journal: Target identification and validation Assay design, development, miniaturization and comparison High throughput/high content/in silico screening and associated technologies Label-free detection technologies and applications Stem cell technologies Biomarkers ADMET/PK/PD methodologies and screening Probe discovery and development, hit to lead optimization Combinatorial chemistry (e.g. small molecules, peptide, nucleic acid or phage display libraries) Chemical library design and chemical diversity Chemo/bio-informatics, data mining Compound management Pharmacognosy Natural Products Research (Chemistry, Biology and Pharmacology of Natural Products) Natural Product Analytical Studies Bipharmaceutical studies of Natural products Drug repurposing Data management and statistical analysis Laboratory automation, robotics, microfluidics, signal detection technologies Current & Future Institutional Research Profile Technology transfer, legal and licensing issues Patents.