Clinical value of prokineticin 2 in the diagnosis of neonatal necrotizing enterocolitis.

IF 4.6 Q2 MATERIALS SCIENCE, BIOMATERIALS
ACS Applied Bio Materials Pub Date : 2024-09-01 Epub Date: 2024-08-23 DOI:10.1080/1354750X.2024.2393342
Qiuli Zeng, Li Zeng, Xiaoyan Yu, Xi Yuan, Wenjing Ma, Zhixin Song, Dapeng Chen
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Abstract

Background: Necrotizing enterocolitis (NEC) is an inflammatory and necrotizing intestinal emergency that occurs in preterm infants and low birth weight newborns; however, no specific serum biomarkers for the diagnosis of NEC has been identified so far.

Methods: Serum samples were collected from healthy neonatal controls and patients with NEC newly admitted to the Children's Hospital of Chongqing Medical University. ELISA was used to measure serum PK2 levels, and ROC curve analysis was sued to evaluate the diagnostic efficacy of PK2 and other clinical biomarkers.

Results: Serum PK2 levels in the NEC group (n = 53) were significantly lower than those in the control group (n = 18), but increased to near-normal levels after the postoperative recovery period. The NLR value of NEC group was higher than that of control group (P < 0.05). There was no significant difference in WBC and PLT count between NEC group and control group (P > 0.05). Serum CRP and PCT levels in NEC group were significantly higher than those in control group (P < 0.001 for CRP and P < 0.05 for PCT, respectively). After surgery, serum CRP, NLR and PCT levels were lower than before surgery, while serum PK2 levels were higher than before surgery (P < 0.05). The areas under the ROC curve (AUC) of PK2, PCT and CRP for the diagnosis of NEC were 0.837, 0.662 and 0.552, respectively. The AUC of PK2 combined with PCT, PK2 combined with CRP, and PK2 combined with PCT and CRP were 0.908, 0.854 and 0.981, respectively. PK2 exhibited the highest diagnostic efficacy for NEC.

Conclusion: PK2 has higher diagnostic efficacy than PCT and CRP in the diagnosis of NEC; the combination of PK2 and PCT or CRP can significantly improve its diagnostic efficiency, especially when the three are combined at the same time.

促红细胞生成素 2 在诊断新生儿坏死性小肠结肠炎中的临床价值。
背景:坏死性小肠结肠炎(NEC坏死性小肠结肠炎(NEC)是一种炎症性坏死性肠道急症,多发于早产儿和低出生体重新生儿,但迄今为止尚未发现诊断NEC的特异性血清标志物。促红细胞生成素 2(PK2)是一种新发现的免疫调节剂,可用于多种炎症性疾病:方法:收集2021年1月1日至2022年1月1日(临床干预前和手术治疗后)健康新生儿对照组和重庆医科大学附属儿童医院新收治的NEC患者的血清样本。采用酶联免疫吸附法测定血清PK2水平,并分析白细胞计数(WBC)、中性粒细胞与淋巴细胞比值(NLR)、降钙素原(PCT)、C反应蛋白(CRP)和血小板(PLT)等指标值;采用接收者操作特征曲线(ROC)分析法比较PK2与上述生物标志物在NEC鉴别诊断中的效率:结果:NEC组(53人)的血清PK2水平明显低于对照组(18人),但在术后恢复期后升至接近正常水平。NEC 组的 NLR 值高于对照组(P 0.05)。NEC 组血清 CRP 和 PCT 水平明显高于对照组(P 结论:PK2 的诊断效果高于 PCT:在诊断 NEC 时,PK2 比 PCT 和 CRP 具有更高的诊断效率,PK2 与 PCT 或 CRP 联用可显著提高其诊断效率,尤其是三者同时联用时。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
ACS Applied Bio Materials
ACS Applied Bio Materials Chemistry-Chemistry (all)
CiteScore
9.40
自引率
2.10%
发文量
464
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