The association between the single-nucleotide polymorphism of site rs1333040 in region 9p21 and the risk of coronary heart disease in Chinese population.

IF 2.1 4区医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS

Acta cardiologica Pub Date : 2024-09-01 Epub Date: 2024-08-15 DOI:10.1080/00015385.2024.2391132

Chen-Hui Zhao

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引用次数: 0

Abstract

Background: Rs1333040 is the single-nucleotide polymorphisms (SNP) related with coronary heart disease (CHD). The aim of the present study is to examine the association between rs1333040 polymorphism genotypes and CHD and to further explore the molecular mechanism in Chinese population.

Methods: A case-control study was used in this study, including 500 CHD patients and 500 control subjects. CHD patients and controls were distinguished by coronary angiography. Genotypes of rs1333040 were determined on the Agena MassARRAY system. Statistical analysis was conducted by SPSS (Ver 16.0) and plink (Ver. 1.07, Shaun Purcell).

Results: Fisher's exact test by plink indicated a significant difference in the allele distribution between cases and controls, the allele T may be associated with a higher risk of CHD (p = 0.012, odds ratio (OR) = 1.258). The serum levels of low-density lipoprotein cholesterol (LDL-C) (p = 0.029) and Gensini score (p = 0.008) distributed differently in patients with various alleles. In the recessive model, the levels of high-density lipoprotein (HDL) and apolipoprotein A (ApoA) were higher in the TC + CC genotype than in the TT genotype. The TC + TT genotype was found to be risk factors against CHD in a dominant model (OR = 1.278, p = 0.014). The TC + TT genotype along with multiple risk factors significantly positively correlated with the risk of CHD.

Conclusions: The present study investigates the association between the rs1333040 polymorphism genotypes and CHD. The T allele of rs1333040 is the susceptibility site of CHD. The interaction between SNP and various risk factors plays an important role in the development of CHD.

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中国人群 9p21 区段 rs1333040 位点的单核苷酸多态性与冠心病风险的关系

背景：Rs1333040是与冠心病（CHD）相关的单核苷酸多态性（SNP）。本研究旨在探讨 rs1333040 多态性基因型与冠心病的相关性，并进一步探索其在中国人群中的分子机制：方法：本研究采用病例对照研究，包括500名CHD患者和500名对照组。CHD 患者和对照组通过冠状动脉造影进行区分。rs1333040 的基因型由 Agena MassARRAY 系统测定。统计分析由 SPSS（版本 16.0）和 plink（版本 1.07，Shaun Purcell）进行：通过 plink 进行的费雪精确检验表明，病例与对照组之间的等位基因分布存在显著差异，等位基因 T 可能与较高的冠心病风险有关（p = 0.012，几率比（OR）= 1.258）。不同等位基因患者的血清低密度脂蛋白胆固醇（LDL-C）水平（p = 0.029）和 Gensini 评分（p = 0.008）分布不同。在隐性模型中，TC + CC 基因型的高密度脂蛋白（HDL）和载脂蛋白 A（ApoA）水平高于 TT 基因型。在显性模型中发现，TC + TT 基因型是导致冠心病的危险因素（OR = 1.278，P = 0.014）。TC+TT基因型与多种危险因素一起与冠心病风险呈显著正相关：本研究调查了 rs1333040 多态性基因型与冠心病之间的关系。rs1333040的T等位基因是CHD的易感位点。SNP与各种危险因素之间的相互作用在CHD的发病中起着重要作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Acta cardiologica 医学-心血管系统

CiteScore

2.50

自引率

12.50%

发文量

115

审稿时长

2 months

期刊介绍： Acta Cardiologica is an international journal. It publishes bi-monthly original, peer-reviewed articles on all aspects of cardiovascular disease including observational studies, clinical trials, experimental investigations with clear clinical relevance and tutorials.