Mapping associations of polygenic scores with autistic and ADHD traits in a single city region.

IF 6.5 1区医学 Q1 PSYCHIATRY

Journal of Child Psychology and Psychiatry Pub Date : 2025-02-01 Epub Date: 2024-08-14 DOI:10.1111/jcpp.14047

Zoe E Reed, Richard Thomas, Andy Boyd, Gareth J Griffith, Tim T Morris, Dheeraj Rai, David Manley, George Davey Smith, Oliver S P Davis

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引用次数: 0

Abstract

Background: The genetic and environmental aetiology of autistic and Attention Deficit Hyperactivity Disorder (ADHD) traits is known to vary spatially, but does this translate into variation in the association of specific common genetic variants?

Methods: We mapped associations between polygenic scores for autism and ADHD and their respective traits in the Avon Longitudinal Study of Parents and Children (N = 4,255-6,165) across the area surrounding Bristol, UK, and compared them to maps of environments associated with the prevalence of autism and ADHD.

Results: Our results suggest genetic associations vary spatially, with consistent patterns for autistic traits across polygenic scores constructed at different p-value thresholds. Patterns for ADHD traits were more variable across thresholds. We found that the spatial distributions often correlated with known environmental influences.

Conclusions: These findings shed light on the factors that contribute to the complex interplay between the environment and genetic influences in autistic and ADHD traits.

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绘制单一城市地区多基因分数与自闭症和多动症特征的关联图。

背景：众所周知，自闭症和注意力缺陷多动障碍（ADHD）特征的遗传和环境病因在空间上存在差异，但这是否会转化为特定常见遗传变异的关联差异？我们绘制了英国布里斯托尔周边地区 "雅芳父母和儿童纵向研究"（N = 4,255-6,165 人）中自闭症和注意力缺陷多动障碍的多基因评分与各自特征之间的关联图，并将其与自闭症和注意力缺陷多动障碍发病率相关的环境图进行比较：结果：我们的研究结果表明，遗传关联在空间上存在差异，自闭症特质的多基因分数在不同的 p 值阈值下具有一致的模式。ADHD特质的模式在不同阈值下变化更大。我们发现，空间分布往往与已知的环境影响因素相关：这些发现揭示了自闭症和多动症特征中环境和遗传影响之间复杂的相互作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Child Psychology and Psychiatry 医学-精神病学

CiteScore

13.80

自引率

5.30%

发文量

169

审稿时长

1 months

期刊介绍： The Journal of Child Psychology and Psychiatry (JCPP) is a highly regarded international publication that focuses on the fields of child and adolescent psychology and psychiatry. It is recognized for publishing top-tier, clinically relevant research across various disciplines related to these areas. JCPP has a broad global readership and covers a diverse range of topics, including: Epidemiology: Studies on the prevalence and distribution of mental health issues in children and adolescents. Diagnosis: Research on the identification and classification of childhood disorders. Treatments: Psychotherapeutic and psychopharmacological interventions for child and adolescent mental health. Behavior and Cognition: Studies on the behavioral and cognitive aspects of childhood disorders. Neuroscience and Neurobiology: Research on the neural and biological underpinnings of child mental health. Genetics: Genetic factors contributing to the development of childhood disorders. JCPP serves as a platform for integrating empirical research, clinical studies, and high-quality reviews from diverse perspectives, theoretical viewpoints, and disciplines. This interdisciplinary approach is a key feature of the journal, as it fosters a comprehensive understanding of child and adolescent mental health. The Journal of Child Psychology and Psychiatry is published 12 times a year and is affiliated with the Association for Child and Adolescent Mental Health (ACAMH), which supports the journal's mission to advance knowledge and practice in the field of child and adolescent mental health.