Xenotransplantation — a shortcut to construct tissue complexity in organoids

IF 3.7 2区 生物学 Q2 CELL BIOLOGY
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引用次数: 0

Abstract

Our knowledge of human biology is mainly originated from studies using animal models. However, interspecies differences between human and model organisms may lead to imprecise extrapolation of results obtained from model organisms. Organoids are three-dimensional cell clusters derived from pluripotent or adult stem cells that self-organize into organ-like structures reminiscent of the cognate organ. The establishment of human organoids makes it possible to study organ or tissue pathophysiology that is specific to human beings. However, most organoids do not have organ-specific vasculature, neurons, and immune cells, hence limiting their utility in emulating complex pathophysiological phenotypes. Among the various approaches to address these limitations, xenotransplantation represents a promising ‘shortcut’. We will discuss recent advance in constructing tissue complexity in organoids, with a special focus on xenotransplantation.

异种移植--在器官组织中构建复杂组织的捷径
我们对人类生物学的了解主要来源于对动物模型的研究。然而,人类与模式生物之间的种间差异可能导致对模型生物研究结果的不精确推断。器官组织是由多能干细胞或成体干细胞衍生的三维细胞簇,可自我组织成类似于相关器官的器官样结构。人体器官组织的建立使研究人体特有的器官或组织病理生理学成为可能。然而,大多数类器官没有器官特异性血管、神经元和免疫细胞,因此限制了它们在模拟复杂病理生理学表型方面的作用。在解决这些限制的各种方法中,异种移植是一种很有前景的 "捷径"。我们将讨论在构建复杂组织器官方面的最新进展,并特别关注异种移植。
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来源期刊
CiteScore
7.90
自引率
0.00%
发文量
102
审稿时长
1 months
期刊介绍: Current Opinion in Genetics and Development aims to stimulate scientifically grounded, interdisciplinary, multi-scale debate and exchange of ideas. It contains polished, concise and timely reviews and opinions, with particular emphasis on those articles published in the past two years. In addition to describing recent trends, the authors are encouraged to give their subjective opinion of the topics discussed. In Current Opinion in Genetics and Development we help the reader by providing in a systematic manner: 1. The views of experts on current advances in their field in a clear and readable form. 2. Evaluations of the most interesting papers, annotated by experts, from the great wealth of original publications.[...] The subject of Genetics and Development is divided into six themed sections, each of which is reviewed once a year: • Cancer Genomics • Genome Architecture and Expression • Molecular and genetic basis of disease • Developmental mechanisms, patterning and evolution • Cell reprogramming, regeneration and repair • Genetics of Human Origin / Evolutionary genetics (alternate years)
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