Prenatal Cannabis and Tobacco Co-Exposure and Its Association with Behavioural Outcomes in Middle Childhood: Co-exposition prénatale au cannabis et au tabac et son association avec les résultats comportementaux au cours de l'enfance intermédiaire.

IF 3.3 3区 医学 Q2 PSYCHIATRY
Emma Nadler, Joanna Jacobus, Rachel A Rabin
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引用次数: 0

Abstract

Objectives: Cannabis legalization has triggered an increase in prenatal cannabis use. Given that tobacco is commonly co-used with cannabis, determining outcomes associated with prenatal cannabis and tobacco co-exposure is crucial. While literature exists regarding the individual effects of prenatal cannabis and tobacco exposure on childhood behaviour, there is a gap regarding their combined use, which may have interactive effects. Therefore, we investigated whether prenatal cannabis and tobacco co-exposure was associated with greater externalizing and internalizing problems in middle childhood compared to prenatal exposure to either substance alone or no exposure.

Methods: Baseline data from the Adolescent Brain Cognitive Development (ABCD) Study (collected in children ages 9-11) were used to explore differences in externalizing and internalizing scores derived from the Childhood Behavior Checklist across four groups: children with prenatal cannabis and tobacco co-exposure (CT, n = 290), children with prenatal cannabis-only exposure (CAN, n = 225), children with prenatal tobacco-only exposure (TOB, n = 966), and unexposed children (CTL, n = 8,311). We also examined if the daily quantity of tobacco exposure modulated the effect of cannabis exposure on outcomes.

Results: Adjusting for covariates, a 2 × 2 ANCOVA revealed significant main effects for prenatal cannabis (p = 0.03) and tobacco exposure (p < 0.001), and a significant interaction effect on externalizing scores (p = 0.032); no significant main effects or interactions were found for internalizing scores. However, interactions between daily quantity of cannabis and tobacco exposure significantly predicted both externalizing and internalizing scores (p < 0.01).

Conclusions: These findings indicate that co-exposure is associated with greater externalizing problems than exposure to either substance alone, which did not differ from each other. Further, greater tobacco exposure may amplify the negative effect of cannabis exposure on both externalizing and internalizing behaviours in children. These findings underscore the need for interventions that target cannabis and tobacco co-use in pregnant women to circumvent their adverse impact on middle childhood behaviour.

产前大麻和烟草共同暴露及其与儿童中期行为结果的关系。
目的:大麻合法化引发了产前大麻使用的增加。鉴于烟草通常与大麻同时使用,因此确定与产前大麻和烟草共同暴露相关的结果至关重要。虽然已有文献介绍了产前接触大麻和烟草对儿童行为的单独影响,但关于它们的联合使用却存在空白,因为这可能会产生交互影响。因此,与产前单独接触或未接触任何一种物质相比,我们研究了产前同时接触大麻和烟草是否会导致儿童中期出现更多的外化和内化问题:方法: 使用青少年大脑认知发展(ABCD)研究(收集 9-11 岁儿童的数据)的基线数据,探讨四组儿童从儿童行为检查表中得出的外化和内化得分的差异:四组儿童:产前同时接触大麻和烟草的儿童(CT,n = 290)、产前仅接触大麻的儿童(CAN,n = 225)、产前仅接触烟草的儿童(TOB,n = 966)以及未接触大麻和烟草的儿童(CTL,n = 8311)。我们还研究了每日烟草暴露量是否会调节大麻暴露对结果的影响:调整协变量后,2 × 2 方差分析显示产前大麻(p = 0.03)和烟草暴露(p p = 0.032)具有显著的主效应;内化评分没有发现显著的主效应或交互作用。然而,每日大麻和烟草暴露量之间的交互作用可显著预测外部化和内部化得分(p 结论:大麻和烟草暴露对儿童的外部化和内部化得分有显著影响:这些研究结果表明,与单独接触任何一种物质相比,同时接触大麻和烟草会导致更严重的外部化问题,而两者之间并无差异。此外,更多地接触烟草可能会扩大接触大麻对儿童外化和内化行为的负面影响。这些研究结果突出表明,有必要针对孕妇同时吸食大麻和烟草的情况采取干预措施,以避免其对儿童中期行为的不利影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
7.00
自引率
2.50%
发文量
69
审稿时长
6-12 weeks
期刊介绍: Established in 1956, The Canadian Journal of Psychiatry (The CJP) has been keeping psychiatrists up-to-date on the latest research for nearly 60 years. The CJP provides a forum for psychiatry and mental health professionals to share their findings with researchers and clinicians. The CJP includes peer-reviewed scientific articles analyzing ongoing developments in Canadian and international psychiatry.
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