Sarcopenia may predict recurrence in patients with head and neck cancer.

IF 4.6 Q2 MATERIALS SCIENCE, BIOMATERIALS
Angela A Colback, Daniel V Arkfeld, Alireza Paydar, Osama Raslan, Daniel J Cates, Marianne Abouyared
{"title":"Sarcopenia may predict recurrence in patients with head and neck cancer.","authors":"Angela A Colback, Daniel V Arkfeld, Alireza Paydar, Osama Raslan, Daniel J Cates, Marianne Abouyared","doi":"10.1002/hed.27903","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Malnutrition is a major consequence of head and neck cancer (HNC), often leading to decreased skeletal muscle mass and impacting survival. The goal of this study is to determine the effect of sarcopenia, as defined by skeletal muscle index (SMI), on survival in patients with HNC.</p><p><strong>Methods: </strong>This is a retrospective review of patients with HNC treated with surgery and/or radiation at a single tertiary care institute. All had pre-treatment imaging available for skeletal muscle index (SMI) measurements, and SMI was calculated at the level of the 3rd cervical vertebra. Sarcopenia was defined as an SMI < 41 cm<sup>2</sup>/m<sup>2</sup> in females and as <43 cm<sup>2</sup>/m<sup>2</sup> in underweight or healthy weight males. Sarcopenia was defined as <53 cm<sup>2</sup>/m<sup>2</sup> in overweight or obese males. Chi-square analysis was performed to compare recurrence and survival rates, and survival analysis was performed via Kaplan-Meir curve.</p><p><strong>Results: </strong>Hundred and twelve patients with HNC were evaluated, 84 men and 28 women with an average age of 60.9 years. Tumors were primarily located in the oral cavity (24.1%) and oropharynx (42%). The majority (69.6%) underwent surgery. Mean body mass index prior to treatment was 28. Sixty-nine patients (61.6%) in our cohort had low SMI. Mean follow-up was 3.9 ± 2.2 years. Recurrence rate was 26% in those with low SMI versus 2% in those without. Patients with low SMI were more likely to have a recurrence (p = 0.02). Overall survival was 72.5% in those with low SMI and 81% in those with normal SMI (p = 0.09).</p><p><strong>Conclusions: </strong>Defining sarcopenia as a low skeletal muscle index at the third cervical vertebra is clinically relevant. This study demonstrates that low SMI at this level, and thus sarcopenia, was strongly associated with higher rates of recurrence.</p>","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":null,"pages":null},"PeriodicalIF":4.6000,"publicationDate":"2024-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"ACS Applied Bio Materials","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1002/hed.27903","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"MATERIALS SCIENCE, BIOMATERIALS","Score":null,"Total":0}
引用次数: 0

Abstract

Background: Malnutrition is a major consequence of head and neck cancer (HNC), often leading to decreased skeletal muscle mass and impacting survival. The goal of this study is to determine the effect of sarcopenia, as defined by skeletal muscle index (SMI), on survival in patients with HNC.

Methods: This is a retrospective review of patients with HNC treated with surgery and/or radiation at a single tertiary care institute. All had pre-treatment imaging available for skeletal muscle index (SMI) measurements, and SMI was calculated at the level of the 3rd cervical vertebra. Sarcopenia was defined as an SMI < 41 cm2/m2 in females and as <43 cm2/m2 in underweight or healthy weight males. Sarcopenia was defined as <53 cm2/m2 in overweight or obese males. Chi-square analysis was performed to compare recurrence and survival rates, and survival analysis was performed via Kaplan-Meir curve.

Results: Hundred and twelve patients with HNC were evaluated, 84 men and 28 women with an average age of 60.9 years. Tumors were primarily located in the oral cavity (24.1%) and oropharynx (42%). The majority (69.6%) underwent surgery. Mean body mass index prior to treatment was 28. Sixty-nine patients (61.6%) in our cohort had low SMI. Mean follow-up was 3.9 ± 2.2 years. Recurrence rate was 26% in those with low SMI versus 2% in those without. Patients with low SMI were more likely to have a recurrence (p = 0.02). Overall survival was 72.5% in those with low SMI and 81% in those with normal SMI (p = 0.09).

Conclusions: Defining sarcopenia as a low skeletal muscle index at the third cervical vertebra is clinically relevant. This study demonstrates that low SMI at this level, and thus sarcopenia, was strongly associated with higher rates of recurrence.

肌少症可预测头颈癌患者的复发。
背景:营养不良是头颈癌(HNC)的一个主要后果,通常会导致骨骼肌质量下降并影响生存。本研究的目的是确定以骨骼肌指数(SMI)定义的肌肉疏松症对 HNC 患者生存的影响:这是一项回顾性研究,研究对象是在一家三级医疗机构接受手术和/或放射治疗的 HNC 患者。所有患者在治疗前都进行了骨骼肌指数(SMI)测量,SMI以第3颈椎水平计算。女性患者的 SMI 为 2/m2,体重不足或体重健康的男性患者的 SMI 为 2/m2,即为 "肌肉疏松症"。超重或肥胖男性的肌肉疏松症定义为 2/m2。对复发率和生存率进行了卡普兰-梅厄曲线生存分析:共评估了 112 名 HNC 患者,其中男性 84 人,女性 28 人,平均年龄 60.9 岁。肿瘤主要位于口腔(24.1%)和口咽(42%)。大多数患者(69.6%)接受了手术治疗。治疗前的平均体重指数为 28。69名患者(61.6%)的SMI较低。平均随访时间为 3.9 ± 2.2 年。低 SMI 患者的复发率为 26%,而非低 SMI 患者的复发率为 2%。低SMI患者更容易复发(P = 0.02)。低SMI患者的总生存率为72.5%,正常SMI患者的总生存率为81%(p = 0.09):结论:将第三颈椎处骨骼肌指数低定义为 "肌肉疏松症 "具有临床意义。本研究表明,该部位的骨骼肌指数低,因此肌肉疏松症与较高的复发率密切相关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
ACS Applied Bio Materials
ACS Applied Bio Materials Chemistry-Chemistry (all)
CiteScore
9.40
自引率
2.10%
发文量
464
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信