Executive function and cortical thickness in biomarker aMCI.

IF 1.4 4区心理学 Q4 CLINICAL NEUROLOGY

Applied Neuropsychology-Adult Pub Date : 2024-08-14 DOI:10.1080/23279095.2024.2389255

David M Scarisbrick, Cierra M Keith, Camila Vieira Ligo Teixeira, Rashi I Mehta, Holly E Phelps, Michelle M Coleman, Melanie Ward, Mark Miller, Osvaldo Navia, Stephanie Pockl, Nafiisah Rajabalee, Gary Marano, Joseph Malone, Pierre F D'Haese, Ali R Rezai, Kirk Wilhelmsen, Marc W Haut

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Abstract

Introduction: Memory deficits are the primary symptom in amnestic Mild Cognitive Impairment (aMCI); however, executive function (EF) deficits are common. The current study examined EF in aMCI based upon amyloid status (A+/A-) and regional atrophy in signature areas of Alzheimer's disease (AD).

Method: Participants included 110 individuals with aMCI (A+ = 66; A- = 44) and 33 cognitively healthy participants (HP). EF was assessed using four neuropsychological assessment measures. The cortical thickness of the AD signature areas was calculated using structural MRI data.

Results: A + had greater EF deficits and cortical atrophy relative to A - in the supramarginal gyrus and superior parietal lobule. A - had greater EF deficits relative to HP, but no difference in signature area cortical thickness.

Discussion: The current study found that the degree of EF deficits in aMCI are a function of amyloid status and cortical thinning in the parietal cortex.

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生物标志物 aMCI 的执行功能和皮质厚度。

简介记忆障碍是失忆性轻度认知功能障碍（aMCI）的主要症状；然而，执行功能（EF）障碍也很常见。本研究根据淀粉样蛋白状态（A+/A-）和阿尔茨海默病（AD）特征性区域萎缩的情况，对 aMCI 的执行功能进行了研究：参与者包括 110 名 aMCI 患者（A+ = 66；A- = 44）和 33 名认知健康参与者（HP）。采用四种神经心理学评估方法对EF进行评估。使用结构性核磁共振成像数据计算AD特征区域的皮质厚度：结果：相对于 A -，A + 的 EF 缺陷和皮质萎缩在边际上回和顶叶上叶更严重。与 HP 相比，A - 的 EF 缺陷更大，但特征区皮质厚度没有差异：讨论：目前的研究发现，aMCI 患者的 EF 缺陷程度与淀粉样蛋白状态和顶叶皮质的皮质变薄有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Applied Neuropsychology-Adult CLINICAL NEUROLOGY-PSYCHOLOGY

CiteScore

4.50

自引率

11.80%

发文量

134

期刊介绍： pplied Neuropsychology-Adult publishes clinical neuropsychological articles concerning assessment, brain functioning and neuroimaging, neuropsychological treatment, and rehabilitation in adults. Full-length articles and brief communications are included. Case studies of adult patients carefully assessing the nature, course, or treatment of clinical neuropsychological dysfunctions in the context of scientific literature, are suitable. Review manuscripts addressing critical issues are encouraged. Preference is given to papers of clinical relevance to others in the field. All submitted manuscripts are subject to initial appraisal by the Editor-in-Chief, and, if found suitable for further considerations are peer reviewed by independent, anonymous expert referees. All peer review is single-blind and submission is online via ScholarOne Manuscripts.