Insights From Omics in Lyme Disease.

IF 5 2区 医学 Q2 IMMUNOLOGY
Linda K Bockenstedt, Alexia A Belperron
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引用次数: 0

Abstract

Lyme disease is a zoonotic infection due to Ixodes tick-transmitted Borrelia burgdorferi sensu lato spirochetes and the most common vector-borne disease in the Northern Hemisphere. Despite nearly 50 years of investigation, the pathogenesis of this infection and its 2 main adverse outcomes-postinfectious Lyme arthritis and posttreatment Lyme disease syndrome-are incompletely understood. Advancement in sequencing and mass spectrometry have led to the rapid expansion of high-throughput omics technologies, including transcriptomics, metabolomics, and proteomics, which are now being applied to human diseases. This review summarizes findings of omics studies conducted on blood and tissue samples of people with acute Lyme disease and its postinfectious outcomes.

莱姆病的分子生物学启示。
莱姆病是一种人畜共患病,由伊科蜱传播的伯氏疏螺旋体引起,是北半球最常见的病媒传染病。尽管经过了近 50 年的研究,但人们对这种感染的发病机制及其 2 种主要不良后果--感染后莱姆关节炎和治疗后莱姆病综合征--仍不完全清楚。测序技术和质谱技术的进步推动了高通量组学技术的快速发展,包括转录组学、代谢组学和蛋白质组学。本综述总结了对急性莱姆病患者的血液和组织样本及其感染后结果进行的全局组学研究的结果。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Journal of Infectious Diseases
Journal of Infectious Diseases 医学-传染病学
CiteScore
13.50
自引率
3.10%
发文量
449
审稿时长
2-4 weeks
期刊介绍: Published continuously since 1904, The Journal of Infectious Diseases (JID) is the premier global journal for original research on infectious diseases. The editors welcome Major Articles and Brief Reports describing research results on microbiology, immunology, epidemiology, and related disciplines, on the pathogenesis, diagnosis, and treatment of infectious diseases; on the microbes that cause them; and on disorders of host immune responses. JID is an official publication of the Infectious Diseases Society of America.
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