Association between endometrial protein expression of IFN-γ and delayed conception after parturition in dairy cows.

IF 1.8 3区 农林科学 Q2 VETERINARY SCIENCES
Veterinary Research Communications Pub Date : 2024-10-01 Epub Date: 2024-08-14 DOI:10.1007/s11259-024-10490-1
M B Peralta, S Cainelli, A F Stassi, E Angeli, F Rey, H H Ortega, N R Salvetti, Mml Velázquez
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引用次数: 0

Abstract

The cytokine context present in the reproductive tract of cows is closely involved in normal uterine functions, including the estrous cycle and the establishment and maintenance of pregnancy. However, the roles of some cytokines in the uterus, and their relation with reproductive performance remain to be elucidated. Thus, this study aimed to examine the protein expression of several cytokines such as TNFα, IL-6, IL-8, IFNγ, IL-4, and TGF-β3 in endometrial biopsies previous to conception, to evaluate the possible association with delayed conception in dairy cows. Protein expression levels were evaluated by immunohistochemistry. Results showed that the protein expression levels of TNFα, IL-6, IL-4 and TGF-β3 were not associated with the parturition-conception interval, whereas the high protein expression levels of IFNγ were associated with the parturition-conception interval. Finally, the low protein expression of IL-8 showed a statistical tendency to be associated with delayed conception. This is the first report about the protein expression of IFN-γ in the endometrium of dairy cows and also, this cytokine could enhance the favorable conditions to achieve an early pregnancy.

Abstract Image

IFN-γ 子宫内膜蛋白表达与奶牛产后受孕延迟之间的关系
奶牛生殖道中的细胞因子与正常的子宫功能密切相关,包括发情周期以及妊娠的建立和维持。然而,一些细胞因子在子宫中的作用及其与繁殖性能的关系仍有待阐明。因此,本研究旨在检测受孕前子宫内膜活检组织中几种细胞因子(如 TNFα、IL-6、IL-8、IFNγ、IL-4 和 TGF-β3)的蛋白表达,以评估其与奶牛受孕延迟的可能关系。蛋白质表达水平通过免疫组化进行评估。结果显示,TNFα、IL-6、IL-4 和 TGF-β3 的蛋白表达水平与分娩-受孕间隔无关,而 IFNγ 的高蛋白表达水平与分娩-受孕间隔有关。最后,IL-8 的低蛋白表达在统计学上显示出与受孕延迟相关的趋势。这是首次报道 IFN-γ 在奶牛子宫内膜中的蛋白表达,而且这种细胞因子还能增强实现早孕的有利条件。
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来源期刊
Veterinary Research Communications
Veterinary Research Communications 农林科学-兽医学
CiteScore
2.50
自引率
0.00%
发文量
173
审稿时长
3 months
期刊介绍: Veterinary Research Communications publishes fully refereed research articles and topical reviews on all aspects of the veterinary sciences. Interdisciplinary articles are particularly encouraged, as are well argued reviews, even if they are somewhat controversial. The journal is an appropriate medium in which to publish new methods, newly described diseases and new pathological findings, as these are applied to animals. The material should be of international rather than local interest. As it deliberately seeks a wide coverage, Veterinary Research Communications provides its readers with a means of keeping abreast of current developments in the entire field of veterinary science.
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