Drug discrimination learning: Interoceptive stimulus control of behavior and its implications for regulated and dysregulated drug intake

IF 3.3 3区 心理学 Q1 BEHAVIORAL SCIENCES
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Abstract

Drug discrimination research has generated rich evidence for the capacity of interoceptive drug stimuli to control behavior by serving as discriminative cues. Owing to its neuropharmacological specificity, drug discrimination learning has been widely used to characterize the stimulus effects and neuropharmacological underpinning of drugs. Apart from such utility, discriminative drug stimuli may help regulate drug use by disambiguating conditioned associations and post-intake outcomes. First, this review summarizes the evidence supporting interoceptive regulation of drug intake from the literature of exteroceptive discriminative control of drug-related behavior, effects of drug priming, and self-titration of drug intake. Second, an overview of interoceptive control of reward-seeking and the animal model of discriminated goal-tracking is provided to illustrate interoceptive stimulus control of the initiation and patterning of drug intake. Third, we highlight the importance of interoceptive control of aversion-avoidance in the termination of drug-use episodes and describe the animal model of discriminated taste avoidance that supports such a position. In bridging these discriminative functions of drug stimuli, we propose that interoceptive drug stimuli help regulate intake by disambiguating whether intake will be rewarding, nonrewarding, or aversive. The reflection and discussion on current theoretical formulations of interoceptive control of drug intake may further scientific advances to improve animal models to study the mechanisms by which interoceptive stimuli regulate drug intake, as well as how alterations of interoceptive processes may contribute to the transition to dysregulated drug use.

药物辨别学习:感知间刺激对行为的控制及其对调节和失调药物摄入的影响。
药物辨别研究提供了丰富的证据,证明感知间药物刺激能够作为辨别线索控制行为。由于其神经药理学特异性,药物辨别学习被广泛用于描述药物的刺激效应和神经药理学基础。除此以外,毒品分辨刺激还可以通过区分条件联想和吸食后的结果来帮助调节药物的使用。首先,本综述总结了从外部感知对药物相关行为的辨别控制、药物引物的影响以及药物摄入的自我调整等文献中支持感知间调节药物摄入的证据。其次,我们概述了对寻求奖赏的感知间控制和辨别目标追踪的动物模型,以说明感知间刺激对药物摄入的启动和模式化的控制。第三,我们强调了对厌恶-回避的感知间控制在终止吸毒事件中的重要性,并描述了支持这一观点的辨别味觉回避动物模型。在衔接药物刺激的这些辨别功能时,我们提出,感知间药物刺激通过区分摄入的是奖励性、非奖励性还是厌恶性,来帮助调节摄入量。对药物摄入感知间控制的现有理论体系进行反思和讨论,可促进科学进步,改善动物模型,以研究感知间刺激调节药物摄入的机制,以及感知间过程的改变如何导致药物使用过渡到失调。
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来源期刊
CiteScore
6.40
自引率
2.80%
发文量
122
审稿时长
38 days
期刊介绍: Pharmacology Biochemistry & Behavior publishes original reports in the areas of pharmacology and biochemistry in which the primary emphasis and theoretical context are behavioral. Contributions may involve clinical, preclinical, or basic research. Purely biochemical or toxicology studies will not be published. Papers describing the behavioral effects of novel drugs in models of psychiatric, neurological and cognitive disorders, and central pain must include a positive control unless the paper is on a disease where such a drug is not available yet. Papers focusing on physiological processes (e.g., peripheral pain mechanisms, body temperature regulation, seizure activity) are not accepted as we would like to retain the focus of Pharmacology Biochemistry & Behavior on behavior and its interaction with the biochemistry and neurochemistry of the central nervous system. Papers describing the effects of plant materials are generally not considered, unless the active ingredients are studied, the extraction method is well described, the doses tested are known, and clear and definite experimental evidence on the mechanism of action of the active ingredients is provided.
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