Severe menopausal symptoms linked to cognitive impairment: an exploratory study.

IF 2.8 3区医学 Q1 OBSTETRICS & GYNECOLOGY

Menopause: The Journal of The North American Menopause Society Pub Date : 2024-11-01 Epub Date: 2024-08-13 DOI:10.1097/GME.0000000000002422

Andrés Calle, Juan E Blümel, Peter Chedraui, María S Vallejo, Alejandra Belardo, Maribel Dextre, Alejandra Elizalde-Cremonte, Carlos Escalante, María T Espinoza, Gustavo Gómez-Tabares, Álvaro Monterrosa-Castro, Mónica Ñañez, Eliana Ojeda, Claudia Rey, Doris Rodríguez, Marcio A Rodrigues, Carlos Salinas, Konstantinos Tserotas, Sócrates Aedo

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引用次数: 0

Abstract

Objective: To evaluate the association between menopausal symptoms and cognitive decline in postmenopausal women.

Methods: This was a subanalysis of a cross-sectional, observational study conducted among women attending gynecological consultations across nine Latin American countries. The survey involved late postmenopausal women who were asked to complete a general questionnaire and the Menopause Rating Scale (MRS) to assess menopausal symptoms, with the Montreal Cognitive Assessment used to evaluate cognitive function as an outcome. A Montreal Cognitive Assessment score of less than 21 was used to define women with mild cognitive impairment (MCI).

Results: The study included 1,287 postmenopausal women with a mean age of 55.5 years and a mean body mass index of 26.3 kg/m 2 . On average, participants had 13.8 years of education and 2.3 ± 1.8 children, with 72.8% reporting having a partner. Additionally, 36.7% ever used menopausal hormone therapy. Regarding lifestyle factors, 50.3% engaged in a sedentary lifestyle, whereas 70.5% had never smoked. 15.3% of women had MCI exhibited significantly more intense menopausal symptoms compared with those without MCI (MRS total score 15.24 ± 12.58 vs 10.53 ± 8.84, respectively, P < 0.001). Logistic regression analysis revealed a significant association between severe menopausal symptoms (MRS total score ≥14 points) and MCI (odds ratio [OR], 1.74; 95% CI, 1.25-2.42). Conversely, a lower body mass index (OR, 0.96; 95% CI, 0.95-0.98), sexual activity (OR, 0.70; 95% CI, 0.51-0.96), physical exercise (OR, 0.55; 95% CI, 0.39-0.76), menopausal hormone therapy use (OR, 0.36; 95% CI, 0.24-0.55), and higher educational level (OR, 0.31; 95% CI, 0.21-0.46) were associated with lower odds for MCI.

Conclusion: Severe menopausal symptoms in postmenopausal women were associated with cognitive impairment. This study highlights the intricate interplay between hormonal, lifestyle, and sociodemographic factors and cognitive health.

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与认知障碍有关的严重更年期症状：一项探索性研究。

目的：评估绝经后妇女更年期症状与认知能力下降之间的关系：评估绝经后妇女更年期症状与认知能力下降之间的关系：这是一项横断面观察性研究的子分析，研究对象是九个拉丁美洲国家的妇科就诊妇女。调查对象为绝经后晚期妇女，要求她们填写一份普通问卷和绝经评分量表（MRS）以评估绝经症状，并使用蒙特利尔认知评估结果来评估认知功能。蒙特利尔认知评估得分低于 21 分的妇女被定义为轻度认知障碍（MCI）：研究对象包括 1,287 名绝经后妇女，她们的平均年龄为 55.5 岁，平均体重指数为 26.3 kg/m2。参与者平均受教育年限为 13.8 年，有 2.3 ± 1.8 个子女，72.8% 有伴侣。此外，36.7%的人曾使用更年期激素治疗。在生活方式方面，50.3%的女性久坐不动，70.5%的女性从不吸烟。与没有 MCI 的女性相比，15.3% 患有 MCI 的女性表现出的更年期症状明显更强烈（MRS 总分分别为 15.24 ± 12.58 vs 10.53 ± 8.84，P < 0.001）。逻辑回归分析显示，严重更年期症状（MRS 总分≥14 分）与 MCI 之间存在显著关联（几率比 [OR]，1.74；95% CI，1.25-2.42）。相反，较低的体重指数（OR，0.96；95% CI，0.95-0.98）、性活动（OR，0.70；95% CI，0.51-0.96）、体育锻炼（OR，0.55；95% CI，0.39-0.76）、使用绝经激素治疗（OR，0.36；95% CI，0.24-0.55）和较高的教育水平（OR，0.31；95% CI，0.21-0.46）与较低的 MCI 发生几率相关：结论：绝经后妇女的严重绝经症状与认知障碍有关。这项研究强调了荷尔蒙、生活方式和社会人口因素与认知健康之间错综复杂的相互作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Menopause: The Journal of The North American Menopause Society 医学-妇产科学

CiteScore

5.40

自引率

7.40%

发文量

330

审稿时长

3-8 weeks

期刊介绍： Menopause, published monthly, provides a forum for new research, applied basic science, and clinical guidelines on all aspects of menopause. The scope and usefulness of the journal extend beyond gynecology, encompassing many varied biomedical areas, including internal medicine, family practice, medical subspecialties such as cardiology and geriatrics, epidemiology, pathology, sociology, psychology, anthropology, and pharmacology. This forum is essential to help integrate these areas, highlight needs for future research, and enhance health care.