Evaluation of the Psychiatric Disorders among Amphetamine Addicts in Rehabilitation Centers: A Cross-Sectional Analysis.

IF 3.4 Q2 TOXICOLOGY
Journal of Toxicology Pub Date : 2024-08-06 eCollection Date: 2024-01-01 DOI:10.1155/2024/1643693
Saud D AlOtaibi, Hossam A Elsisi, Mohammed J AlShammary, Saud A AlQader, Hejab A AlHarbi, Bayan R AlOlaiyan, Ahmad O Alanazi, Firas S AlMendeel, Yazeed N AlHarbi, Ibrahim AlKhalaf, Ahmad H Alhowail, Abdelhamid Mohamed Elwy, Ashraf M Emara
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引用次数: 0

Abstract

Background: People who are addicted to amphetamines have a much greater chance of developing psychosis compared to those who are not. It is essential to study the behavioral and psychological effects of amphetamines. Therefore, this research aimed to examine conditions such as depression, anxiety, mood, cognitive abilities at the workplace, and social responsibilities by using sociodemographic factors as useful tools in determining effective strategies for preventing, managing, and treating amphetamine addiction.

Methods: A cross-sectional study among addicts hospitalized at two rehabilitation centers across Saudi Arabia between May and October 2023. A validated questionnaire consisting of psychiatric disorders assessment tools was distributed to healthcare professionals to start an interview with addicts to assess the abnormalities. The results were compared with healthy people (control). The assessment tools used are Hamilton Anxiety and Depression Rating Scale, Young Mania Rating Scale, and Work and Social Adjustment Scale. The data were analyzed using SPSS version 22.0. Pearson correlation coefficients (r) were employed.

Results: A total of 60 subjects participated in this study. The participants were divided into two groups (n = 60): group I was control (n = 25) healthy volunteers and group II was amphetamine abusers (n = 35), who were hospitalized for detoxification. The ages ranged from 18 to 60 years old with mean ages of 38.68 (±8.14) and 37.77 (±10.95) years in the control and amphetamine groups, respectively. Among the addicts, the mean severity dependence scale value was 10.46 (±1.82), which denotes high dependency on the illicit drug. The prevalence of high levels of anxiety, depression, and bipolar disorder was significantly higher among addicts when they were compared to healthy people (control). The assessment of the Work and Social Adjustment Scale (WSAS) reflected a higher impairment that minimized their ability to perform the work requirements, home management, social leisure, and relationships.

Conclusions: The addiction to amphetamines was associated with high impairment of work performance and social obligations and a negative impact on the addict's mental health. The risk of suffering anxiety, depression, and bipolar is higher than in nonaddict people. These effects are attributed to brain damage, neurotoxicity, and neuronal inflammation, particularly when these substances are abused over extended periods and at higher doses.

评估康复中心苯丙胺成瘾者的精神障碍:横断面分析
背景:与不吸食苯丙胺的人相比,吸食苯丙胺成瘾的人患精神病的几率要大得多。研究苯丙胺对行为和心理的影响至关重要。因此,本研究旨在通过将社会人口学因素作为有用工具,研究抑郁、焦虑、情绪、工作场所认知能力和社会责任等状况,以确定预防、管理和治疗苯丙胺成瘾的有效策略:对 2023 年 5 月至 10 月期间在沙特阿拉伯两家康复中心住院的成瘾者进行横断面研究。研究人员向医护人员发放了由精神障碍评估工具组成的有效问卷,开始对成瘾者进行访谈,以评估其异常情况。调查结果与健康人(对照组)进行了比较。使用的评估工具包括汉密尔顿焦虑抑郁评定量表、青年躁狂评定量表和工作与社会适应量表。数据使用 SPSS 22.0 版进行分析。结果:共有 60 名受试者参加了此次研究。参与者分为两组(n = 60):第一组为对照组(n = 25)健康志愿者,第二组为住院戒毒的苯丙胺滥用者(n = 35)。年龄从 18 岁到 60 岁不等,对照组和苯丙胺滥用者的平均年龄分别为 38.68 岁(±8.14)和 37.77 岁(±10.95)。在成瘾者中,严重依赖量表的平均值为 10.46 (±1.82),表示对非法药物的高度依赖。与健康人(对照组)相比,吸毒成瘾者的焦虑症、抑郁症和躁郁症发病率明显较高。工作和社会适应量表(WSAS)的评估结果显示,成瘾者在工作要求、家庭管理、社会休闲和人际关系方面的能力受损程度较高:安非他明成瘾与工作表现和社会义务的高度受损以及对成瘾者心理健康的负面影响有关。焦虑、抑郁和躁狂症的患病风险高于非成瘾者。这些影响归因于脑损伤、神经毒性和神经元炎症,尤其是在长期和高剂量滥用这些物质的情况下。
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来源期刊
Journal of Toxicology
Journal of Toxicology TOXICOLOGY-
CiteScore
5.50
自引率
3.40%
发文量
0
审稿时长
10 weeks
期刊介绍: Journal of Toxicology is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies in all areas of toxicological sciences. The journal will consider articles looking at the structure, function, and mechanism of agents that are toxic to humans and/or animals, as well as toxicological medicine, risk assessment, safety evaluation, and environmental health.
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