Hypothalamus-pituitary-adrenal axis in patients with post-traumatic stress disorders and related to oxidative stress.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-08-14 DOI:10.1515/hmbci-2024-0017

Ali M A Al-Kufaishi, Noor J T Al-Musawi

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Abstract

Objectives: The study involves the effect of hypothalamus-pituitary-adrenal hormones disorders, and related to oxidative stress in individuals with PTSD to those in the healthy group after they experience a specific event that results in a congenital illness or limb loss.

Methods: Obtaining serum samples from males exclusively in cases where psychiatrists have determined that the men have experienced psychological damage brought on by a particular tragedy, and testing the men for hypothalamus-pituitary-adrenal axis and oxidative stress parameters in comparison to healthy participants.

Results: It was observed that there was a notable rise in cortisol levels (5.60 ± 0.93) at 4 pm compared with healthy control (3.43 ± 0.64) resulting from the stimulating effect of the pituitary gland, and this increase has a role in raising levels of oxidative stress in patients total oxidant status (1.08 ± 0.13) compared with control (0.70 ± 0.10). High oxidative stress may lead to increased prolactin levels and decreased testosterone levels.

Conclusions: Transmission of incorrect chemical signals from the central nervous system has a role in causing disturbances in hormonal levels of the hypothalamus and its associated glands, and thus an imbalance in the metabolic rate due to high cortisol. Also, high levels of prolactin hormones play a role in a significant decrease in testosterone levels.

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创伤后应激障碍患者的下丘脑-垂体-肾上腺轴与氧化应激的关系。

研究目的该研究涉及创伤后应激障碍患者与健康组患者在经历导致先天性疾病或肢体缺失的特定事件后，下丘脑-垂体-肾上腺激素紊乱以及氧化应激的相关影响：方法：在精神科医生认定男性经历了特定悲剧带来的心理伤害的情况下，专门采集男性血清样本，并与健康参与者对比，检测男性下丘脑-垂体-肾上腺轴和氧化应激参数：结果发现，与健康对照组（3.43 ± 0.64）相比，下午 4 点时皮质醇水平（5.60 ± 0.93）明显升高，这是由于脑垂体的刺激作用所致；与对照组（0.70 ± 0.10）相比，皮质醇水平（1.08 ± 0.13）的升高有助于提高患者总氧化应激状态的氧化应激水平。高氧化应激可能导致催乳素水平升高和睾酮水平降低：结论：中枢神经系统传递错误的化学信号会导致下丘脑及其相关腺体的激素水平紊乱，从而使皮质醇过高导致新陈代谢率失衡。此外，催乳激素水平过高也会导致睾酮水平显著下降。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.