Association between COVID-19 infection and uveitis flare in patients with Behcet's disease, a retrospective multicenter cohort study.

IF 2.4 3区医学 Q2 OPHTHALMOLOGY

Graefe’s Archive for Clinical and Experimental Ophthalmology Pub Date : 2025-01-01 Epub Date: 2024-08-14 DOI:10.1007/s00417-024-06536-4

Hang Song, Yuelun Zhang, Ying Chen, Meifen Zhang, Fei Gao, Chan Zhao

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引用次数: 0

Abstract

Purpose: To explore if COVID-19 infection and its subsequent immunosuppressant adjustment as well as previous vaccination status are associated with higher risks of uveitis flare in patients with Behcet's disease.

Methods: This retrospective multicenter cohort study was conducted in January 2023 among patients with Behcet's uveitis, during the second wave of the COVID-19 pandemic in China, with an anticipated sample size of 250. The primary objective was to examine the association between COVID-19 infection and the occurrence of uveitis flare. The potential impact of other exposures, including the patient's vaccination status and treatment adjustments to the risk of uveitis flare and the course of COVID-19 infection were also analyzed.

Results: 207 patients with COVID-19 infection and 47 patients without COVID-19 infection were included. A total of 127 uveitis flares occurred in the observational period (14.29 events per 100 person-month). COVID-19 infection was found to be significantly associated with a higher rate of uveitis flare (adjusted rate ratio = 4.8, 95% CI 3.7 to 6.3, P < 0.001). However, neither systemic immunosuppressive adjustment nor COVID-19 vaccination status showed a significant association with uveitis flare or the course of COVID-19 infection.

Conclusions: This study provides evidence of an association between COVID-19 infection and an increased risk of uveitis flare in patients with Behcet's disease. However, there was no significant evidence to support that baseline immunosuppressive therapy regimens, treatment adjustment after COVID-19 infection, or vaccination status were associated with higher risks of uveitis flare or prolonged COVID-19 course.

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COVID-19感染与白塞氏病患者葡萄膜炎复发之间的关系，一项回顾性多中心队列研究。

目的：探讨COVID-19感染及其随后的免疫抑制剂调整以及既往的疫苗接种情况是否与白塞氏病患者葡萄膜炎复发的较高风险有关：这项回顾性多中心队列研究于2023年1月在中国第二波COVID-19大流行期间在白塞氏葡萄膜炎患者中开展，预计样本量为250人。主要目的是研究COVID-19感染与葡萄膜炎复发之间的关联。研究还分析了其他暴露因素（包括患者的疫苗接种情况和治疗调整）对葡萄膜炎复发风险和COVID-19感染病程的潜在影响。观察期间共发生了127例葡萄膜炎复发（每百人月14.29例）。研究发现，COVID-19 感染与葡萄膜炎复发率的升高有显著相关性（调整后的比率比 = 4.8，95% CI 3.7 至 6.3，P 结论：COVID-19 感染与葡萄膜炎复发率的升高有显著相关性：本研究提供了白塞氏病患者感染 COVID-19 与葡萄膜炎复发风险增加之间存在关联的证据。然而，没有重要证据支持基线免疫抑制治疗方案、COVID-19 感染后的治疗调整或疫苗接种状况与葡萄膜炎复发或 COVID-19 病程延长的风险增加有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Graefe’s Archive for Clinical and Experimental Ophthalmology 医学-眼科学

CiteScore

5.40

自引率

7.40%

发文量

398

审稿时长

3 months

期刊介绍： Graefe''s Archive for Clinical and Experimental Ophthalmology is a distinguished international journal that presents original clinical reports and clini-cally relevant experimental studies. Founded in 1854 by Albrecht von Graefe to serve as a source of useful clinical information and a stimulus for discussion, the journal has published articles by leading ophthalmologists and vision research scientists for more than a century. With peer review by an international Editorial Board and prompt English-language publication, Graefe''s Archive provides rapid dissemination of clinical and clinically related experimental information.