A Retrospective Cytomorphologic Analysis of Salivary Gland Fine Needle Aspirates Classified as Salivary Gland Neoplasm of Uncertain Malignant Potential: A 6-year Institutional Experience

IF 1 4区医学 Q4 MEDICAL LABORATORY TECHNOLOGY

Diagnostic Cytopathology Pub Date : 2024-08-14 DOI:10.1002/dc.25395

Shweta Agarwal

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引用次数: 0

Abstract

Background

The Milan System for Reporting Salivary Gland Cytopathology is an effective reporting system for salivary gland fine needle aspirations with well-established risks of malignancy. Salivary gland neoplasm of uncertain malignant potential (SUMP) comprises a heterogenous group of lesions which have features that can be recognized as at least neoplastic but preclude further classification into benign or malignant. In this study, we reviewed the cytomorphologic features of salivary gland fine needle aspirations diagnosed as SUMP at our institution (over the past 6 years) and correlated those with the final diagnosis on surgical follow up.

Design

A retrospective search was performed to identify cases classified as SUMP at our institution from January 2018 to February 2024. Cytology slides were reviewed, and cases were subclassified based on key cytomorphologic features into the following categories: (1) basaloid, (2) oncocytic, (3) with clear cell features and (4) mixed features (myoepithelial/oncocytoid/squamoid features). Histologic diagnosis was recorded if available.

Results

A total of 36 cases of SUMP were identified; 31/36 had surgical follow up; final diagnosis included 22 benign lesions (2 non-neoplastic and 20 benign neoplasms), and nine malignant lesions. The overall risk of neoplasm and risk of malignancy were 93.5% and 29% respectively, with the oncocytic sub-category recording the highest ROM (42.8%). Mucoepidermoid carcinoma was the most common malignant diagnosis and pleomorphic adenoma the most common benign diagnoses.

Conclusions

Our study supports the subclassification of SUMP lesions based on key cytomorphologic features, thereby aiding in refining this ambiguous entity and providing a precise risk assessment.

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涎腺细针吸痰细胞形态学回顾性分析--归类为恶性可能性不确定的涎腺肿瘤：6年机构经验。

背景：米兰唾液腺细胞病理学报告系统（Milan System for Reporting Salivary Gland Cytopathology）是一种有效的唾液腺细针穿刺报告系统，其恶性风险已得到充分证实。恶性潜能不确定的唾液腺肿瘤（SUMP）包括一组异质性病变，其特征至少可被认定为肿瘤性，但无法进一步分为良性或恶性。在本研究中，我们回顾了本院（过去 6 年）诊断为 SUMP 的唾液腺细针穿刺的细胞形态学特征，并将这些特征与手术随访的最终诊断结果进行了关联：通过回顾性检索，确定我院在2018年1月至2024年2月期间归类为SUMP的病例。对细胞学切片进行审查，并根据关键的细胞形态学特征将病例细分为以下几类：(1)基底细胞型；(2)肿瘤细胞型；(3)透明细胞型；(4)混合型（肌上皮型/肿瘤细胞型/鳞状上皮型）。如果有组织学诊断结果，则予以记录：共发现 36 例 SUMP；31/36 进行了手术随访；最终诊断包括 22 例良性病变（2 例非肿瘤和 20 例良性肿瘤）和 9 例恶性病变。肿瘤总风险和恶性风险分别为93.5%和29%，其中肿瘤细胞亚类的ROM最高（42.8%）。黏液表皮样癌是最常见的恶性诊断，而多形性腺瘤则是最常见的良性诊断：我们的研究支持根据关键的细胞形态学特征对 SUMP 病变进行亚分类，从而有助于完善这一模糊的实体并提供精确的风险评估。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Diagnostic Cytopathology 医学-病理学

CiteScore

2.60

自引率

7.70%

发文量

163

审稿时长

3-6 weeks

期刊介绍： Diagnostic Cytopathology is intended to provide a forum for the exchange of information in the field of cytopathology, with special emphasis on the practical, clinical aspects of the discipline. The editors invite original scientific articles, as well as special review articles, feature articles, and letters to the editor, from laboratory professionals engaged in the practice of cytopathology. Manuscripts are accepted for publication on the basis of scientific merit, practical significance, and suitability for publication in a journal dedicated to this discipline. Original articles can be considered only with the understanding that they have never been published before and that they have not been submitted for simultaneous review to another publication.