Loss of clear cell characteristics in aggressive clear cell odontogenic carcinoma: a case report.

IF 4.6 Q2 MATERIALS SCIENCE, BIOMATERIALS
Yanan Sun, Bo Li, Yaying Hu, Fu Chen, Junchen Pan, Yi Zhou, Jiali Zhang
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引用次数: 0

Abstract

Background: Clear cell odontogenic carcinoma (CCOC) is an odontogenic carcinoma characterized by sheets and islands of vacuolated and clear cells. The diagnosis of atypical CCOC can pose a challenge when tumor cells deviate from their characteristic clear morphology, even with the aid of genetic profiling for CCOC identification.

Case presentation: In this manuscript, we detailed the inaugural instance of a recurrently recurring clear cell odontogenic carcinoma (CCOC) with pronounced squamous differentiation in a 64-year-old male. The primary tumor in this individual initially displayed a biphasic clear cell phenotype. However, subsequent to the third recurrence, the clear tumor cells were entirely supplanted by epidermoid cells characterized by eosinophilic cytoplasm, vesicular chromatin, and prominent nucleoli. Notable aggressive attributes such as necrosis, conspicuous cytological malignancy, perineural dissemination, and vascular invasion were noted. Additionally, the tumor progressed to manifest lung metastases. The tumor cells exhibited positive immunoreactivity for AE1/AE3, KRT19, Pan-CK, EMA, P40, P63, CK34βE12, and P53, while they tested negative for CK35βH11, KRT7, S-100, and neuroendocrine markers. The Ki-67 proliferation index was calculated at an average of 15%. Furthermore, FISH analysis unveiled the presence of the EWSR1::ATF1 gene fusion.

Conclusions: This case illustrated a rare and aggressive case of CCOC characterized by significant squamous differentiation upon recurrence of the tumor.

侵袭性透明细胞牙源性癌丧失透明细胞特征:病例报告。
背景:透明细胞牙源性癌(CCOC)是一种以成片和成岛的空泡透明细胞为特征的牙源性癌。当肿瘤细胞偏离其特有的透明形态时,非典型 CCOC 的诊断就会面临挑战,即使借助基因图谱来鉴定 CCOC 也是如此:在本手稿中,我们详细介绍了一名 64 岁男性反复复发的透明细胞牙源性癌(CCOC)的首次病例,该肿瘤具有明显的鳞状分化。该患者的原发肿瘤最初表现为双相透明细胞表型。然而,在第三次复发后,透明瘤细胞完全被表皮样细胞取代,表皮样细胞的特征是嗜酸性细胞质、水泡状染色质和突出的核小体。肿瘤具有明显的侵袭性特征,如坏死、明显的细胞恶性、会厌扩散和血管侵犯。此外,肿瘤发展到肺部转移。肿瘤细胞对 AE1/AE3、KRT19、Pan-CK、EMA、P40、P63、CK34βE12 和 P53 呈阳性免疫反应,而对 CK35βH11、KRT7、S-100 和神经内分泌标志物呈阴性反应。经计算,Ki-67增殖指数平均为15%。此外,FISH分析揭示了EWSR1::ATF1基因融合的存在:本病例是一例罕见的侵袭性 CCOC 病例,其特点是肿瘤复发后出现明显的鳞状分化。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
ACS Applied Bio Materials
ACS Applied Bio Materials Chemistry-Chemistry (all)
CiteScore
9.40
自引率
2.10%
发文量
464
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