Novel microwave assisted carboxymethyl-graphene oxide and its hepatoprotective activity.

IF 2.8 3区医学 Q2 PHARMACOLOGY & PHARMACY

BMC Pharmacology & Toxicology Pub Date : 2024-08-13 DOI:10.1186/s40360-024-00768-0

Hebat-Allah S Tohamy, Fatma El-Zahraa S Mohamed, Mohamed El-Sakhawy

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Abstract

This study reports a novel, eco-friendly; fast and cost-effective microwave method for synthesizing carboxymethylated graphene oxide (CMGO) from sugarcane residues. Fourier-transform infrared spectroscopy (FTIR) confirmed successful CMGO synthesis through the presence of characteristic peaks at 1567.93 and 1639.29 cm^-1 (COONa vibrations) and increased CH₂ intensity compared to unmodified graphene oxide (GO). Furthermore, CMGO derived from sugarcane residues demonstrated potential in mitigating the side effects of toxic materials like carbon tetrachloride (CCl₄). Treatment with CMGO partially reduced elevated levels of liver enzymes (ALT and AST) and nitrogenous waste products (urea and uric acid) in CCl₄-induced liver damage models, suggesting an improvement in liver function despite ongoing cellular damage.This work paves the way for a sustainable and economical approach to produce functionalized graphene oxide with promising biomedical applications in alleviating toxin-induced liver injury.

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新型微波辅助羧甲基氧化石墨烯及其保肝活性。

本研究报告了一种利用甘蔗残渣合成羧甲基氧化石墨烯（CMGO）的新型、环保、快速且经济有效的微波方法。傅立叶变换红外光谱（FTIR）证实，与未改性的氧化石墨烯（GO）相比，CMGO 在 1567.93 和 1639.29 cm-1 处出现了特征峰（COONa 振荡），且 CH2 强度增加，从而成功合成了 CMGO。此外，从甘蔗残渣中提取的 CMGO 在减轻四氯化碳（CCl4）等有毒物质的副作用方面具有潜力。在 CCl4 诱导的肝损伤模型中，用 CMGO 治疗可部分降低肝酶（谷丙转氨酶和谷草转氨酶）和含氮废物（尿素和尿酸）水平的升高，这表明尽管细胞持续受损，但肝功能仍得到了改善。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

BMC Pharmacology & Toxicology PHARMACOLOGY & PHARMACYTOXICOLOGY&nb-TOXICOLOGY

CiteScore

4.80

自引率

0.00%

发文量

审稿时长

12 weeks

期刊介绍： BMC Pharmacology and Toxicology is an open access, peer-reviewed journal that considers articles on all aspects of chemically defined therapeutic and toxic agents. The journal welcomes submissions from all fields of experimental and clinical pharmacology including clinical trials and toxicology.