Pollen effects in a changing climate: Ragweed pollen exposure and sleepiness in immunotherapy patients of a Southeastern Michigan allergy clinic

IF 3 3区 地球科学 Q2 BIOPHYSICS
Peter S. Larson, Allison L. Steiner, Erica Bennion, Alan P. Baptist, Marie S. O’Neill, Carina J. Gronlund
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Abstract

Allergic rhino-conjunctivitis (AR) is a globally relevant health disorder characterized by sneezing, rhinorrhea and sleep disturbance. Ragweed (Ambrosia artemisiifolia) is a plant common to North America and an important allergen. Coarse methods of measuring airborne pollen counts are used to predict seasonal allergy symptoms. This research used a longitudinal study design with a novel, model-based raster of predicted pollen counts to test associations with self-reported symptoms of AR collected from patients receiving immunotherapy for pollen allergies at an allergy clinic. Researchers visited a clinic six times over three weeks. Immunotherapy patients were asked to fill out a brief intake survey on allergic and symptomatic profiles, daytime sleepiness, housing quality, and demographics. Participants responded to a daily, emailed survey on sleepiness and asthma symptoms for 21 days. Using the date and location of responses, ragweed pollen counts were extracted from a prognostic, model based raster (25km pixels). Lag associations of pollen counts with sleepiness were tested using a logistic regression model , adjusted for housing and demographic characteristics, in a distributed lag non-linear model (DLNM) framework. 49 people participated in the study. 26 (52%) were female. The mean age was 37.9 years. Asthma/allergy symptoms were not associated with ragweed pollen but sleepiness was highest two days after exposure (Estimate: 0.33 [0.04,0.62]). Subjects traveled widely during the study period. Intense exposures to ragweed pollen may be associated with daytime sleepiness within small exposure windows. Model-based predicted pollen counts could be used to study health impacts of pollen in people with disease severe enough to receive immunotherapy. Daytime sleepiness can affect productivity and injury risk, and pollen season length and allergenicity may be increasing with climate change. Thus our results may have important implications for population health.

Abstract Image

Abstract Image

不断变化的气候中的花粉效应:密歇根州东南部一家过敏诊所的豚草花粉暴露与免疫疗法患者的嗜睡。
过敏性鼻结膜炎(AR)是一种全球性的健康疾病,以打喷嚏、鼻出血和睡眠障碍为特征。豚草(Ambrosia artemisiifolia)是北美常见的一种植物,也是一种重要的过敏原。测量空气中花粉数量的粗略方法可用于预测季节性过敏症状。这项研究采用纵向研究设计,利用基于模型的新型预测花粉数量栅格,测试过敏诊所从接受花粉过敏免疫疗法的患者那里收集的 AR 症状与自我报告症状之间的关联。研究人员在三周内对一家诊所进行了六次访问。免疫治疗患者被要求填写一份简短的入院调查,内容包括过敏和症状概况、白天嗜睡情况、住房质量和人口统计数据。在 21 天内,参与者每天都会通过电子邮件回复有关嗜睡和哮喘症状的调查。利用回复的日期和地点,从基于模型的预报栅格(25 千米像素)中提取豚草花粉数量。在分布式滞后非线性模型(DLNM)框架内,使用逻辑回归模型检验了花粉数量与嗜睡的滞后关系,并对住房和人口特征进行了调整。49人参与了研究。其中 26 人(52%)为女性。平均年龄为 37.9 岁。哮喘/过敏症状与豚草花粉无关,但在接触豚草花粉两天后嗜睡程度最高(估计值:0.33 [0.04,0.62])。受试者在研究期间四处旅行。强烈接触豚草花粉可能与小范围内的白天嗜睡有关。基于模型预测的花粉数量可用于研究花粉对疾病严重到需要接受免疫疗法的人群的健康影响。白天嗜睡会影响工作效率和受伤风险,而花粉季节的长度和过敏性可能会随着气候变化而增加。因此,我们的研究结果可能会对人群健康产生重要影响。
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来源期刊
CiteScore
6.40
自引率
9.40%
发文量
183
审稿时长
1 months
期刊介绍: The Journal publishes original research papers, review articles and short communications on studies examining the interactions between living organisms and factors of the natural and artificial atmospheric environment. Living organisms extend from single cell organisms, to plants and animals, including humans. The atmospheric environment includes climate and weather, electromagnetic radiation, and chemical and biological pollutants. The journal embraces basic and applied research and practical aspects such as living conditions, agriculture, forestry, and health. The journal is published for the International Society of Biometeorology, and most membership categories include a subscription to the Journal.
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