Urinary and Fecal Excretion of 121 Environmental Chemicals in Pet Dogs and Cats: Significance of Feces in Biomonitoring of Exposures

IF 11.3 1区 环境科学与生态学 Q1 ENGINEERING, ENVIRONMENTAL
Zhong-Min Li,  and , Kurunthachalam Kannan*, 
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Abstract

Laboratory animal studies have reported the biliary excretion of chemicals following exposure. Nevertheless, feces are rarely used as a matrix in biomonitoring of chemical exposures. In this study, feces and urine from pet dogs and cats were analyzed for the presence of 45 plasticizers, 45 environmental phenols, and 31 pesticides. Thirty-two analytes were detected in ≥70% pet feces, while up to 29 analytes were frequently (≥70%) found in urine. The sum concentrations of all analytes (∑All) in pet feces were significantly higher than those measured in urine (median: 393–666 ng/g wet weight in feces vs 216–464 ng/mL in urine). Plasticizers were the dominant class of chemicals, accounting for 81–97% and 69–77% of ∑All in urine and feces, respectively. Analyte concentrations measured in paired urine and feces exhibited weak correlations. The excretion rates of the chemicals via urine and feces were calculated through a reverse dosimetry approach. Low-molecular-weight phthalates excreted predominantly in urine, whereas high-molecular-weight phthalates and several organophosphate triesters were excreted predominantly in feces. The fecal excretion rates of parabens, benzophenones, bisphenols, naphthalene, 2,4-dichloronicotinic acid, and 4-nitrophenol were similar to or higher than those of urinary excretion. Our results suggest that feces are an important matrix in biomonitoring of exposure to environmental chemicals.

Abstract Image

宠物猫狗体内 121 种环境化学品的尿液和粪便排泄物:粪便在生物监测暴露中的意义
实验动物研究报告了接触化学品后的胆汁排泄情况。然而,粪便很少被用作化学品暴露生物监测的基质。在这项研究中,对宠物狗和宠物猫的粪便和尿液进行了分析,以检测其中是否含有 45 种增塑剂、45 种环境酚类和 31 种杀虫剂。在≥70%的宠物粪便中检测到 32 种分析物,而在尿液中检测到多达 29 种分析物(≥70%)。宠物粪便中所有分析物(∑All)的浓度总和明显高于尿液中的测定值(中位数:粪便中为 393-666 纳克/克湿重,尿液中为 216-464 纳克/毫升)。增塑剂是最主要的一类化学品,分别占尿液和粪便中∑All的81-97%和69-77%。在配对尿液和粪便中测得的分析物浓度显示出微弱的相关性。化学物质通过尿液和粪便的排泄率是通过反向剂量测定法计算得出的。低分子量的邻苯二甲酸盐主要通过尿液排出,而高分子量的邻苯二甲酸盐和几种有机磷三酯则主要通过粪便排出。对羟基苯甲酸酯、二苯甲酮、双酚、萘、2,4-二氯烟酸和 4-硝基苯酚的粪便排泄率与尿液排泄率相似或更高。我们的研究结果表明,粪便是环境化学物质暴露生物监测的重要基质。
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来源期刊
环境科学与技术
环境科学与技术 环境科学-工程:环境
CiteScore
17.50
自引率
9.60%
发文量
12359
审稿时长
2.8 months
期刊介绍: Environmental Science & Technology (ES&T) is a co-sponsored academic and technical magazine by the Hubei Provincial Environmental Protection Bureau and the Hubei Provincial Academy of Environmental Sciences. Environmental Science & Technology (ES&T) holds the status of Chinese core journals, scientific papers source journals of China, Chinese Science Citation Database source journals, and Chinese Academic Journal Comprehensive Evaluation Database source journals. This publication focuses on the academic field of environmental protection, featuring articles related to environmental protection and technical advancements.
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