{"title":"Urinary and Fecal Excretion of 121 Environmental Chemicals in Pet Dogs and Cats: Significance of Feces in Biomonitoring of Exposures","authors":"Zhong-Min Li, and , Kurunthachalam Kannan*, ","doi":"10.1021/acs.est.4c0599110.1021/acs.est.4c05991","DOIUrl":null,"url":null,"abstract":"<p >Laboratory animal studies have reported the biliary excretion of chemicals following exposure. Nevertheless, feces are rarely used as a matrix in biomonitoring of chemical exposures. In this study, feces and urine from pet dogs and cats were analyzed for the presence of 45 plasticizers, 45 environmental phenols, and 31 pesticides. Thirty-two analytes were detected in ≥70% pet feces, while up to 29 analytes were frequently (≥70%) found in urine. The sum concentrations of all analytes (∑All) in pet feces were significantly higher than those measured in urine (median: 393–666 ng/g wet weight in feces vs 216–464 ng/mL in urine). Plasticizers were the dominant class of chemicals, accounting for 81–97% and 69–77% of ∑All in urine and feces, respectively. Analyte concentrations measured in paired urine and feces exhibited weak correlations. The excretion rates of the chemicals via urine and feces were calculated through a reverse dosimetry approach. Low-molecular-weight phthalates excreted predominantly in urine, whereas high-molecular-weight phthalates and several organophosphate triesters were excreted predominantly in feces. The fecal excretion rates of parabens, benzophenones, bisphenols, naphthalene, 2,4-dichloronicotinic acid, and 4-nitrophenol were similar to or higher than those of urinary excretion. Our results suggest that feces are an important matrix in biomonitoring of exposure to environmental chemicals.</p>","PeriodicalId":36,"journal":{"name":"环境科学与技术","volume":"58 32","pages":"14169–14179 14169–14179"},"PeriodicalIF":11.3000,"publicationDate":"2024-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"环境科学与技术","FirstCategoryId":"1","ListUrlMain":"https://pubs.acs.org/doi/10.1021/acs.est.4c05991","RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ENGINEERING, ENVIRONMENTAL","Score":null,"Total":0}
引用次数: 0
Abstract
Laboratory animal studies have reported the biliary excretion of chemicals following exposure. Nevertheless, feces are rarely used as a matrix in biomonitoring of chemical exposures. In this study, feces and urine from pet dogs and cats were analyzed for the presence of 45 plasticizers, 45 environmental phenols, and 31 pesticides. Thirty-two analytes were detected in ≥70% pet feces, while up to 29 analytes were frequently (≥70%) found in urine. The sum concentrations of all analytes (∑All) in pet feces were significantly higher than those measured in urine (median: 393–666 ng/g wet weight in feces vs 216–464 ng/mL in urine). Plasticizers were the dominant class of chemicals, accounting for 81–97% and 69–77% of ∑All in urine and feces, respectively. Analyte concentrations measured in paired urine and feces exhibited weak correlations. The excretion rates of the chemicals via urine and feces were calculated through a reverse dosimetry approach. Low-molecular-weight phthalates excreted predominantly in urine, whereas high-molecular-weight phthalates and several organophosphate triesters were excreted predominantly in feces. The fecal excretion rates of parabens, benzophenones, bisphenols, naphthalene, 2,4-dichloronicotinic acid, and 4-nitrophenol were similar to or higher than those of urinary excretion. Our results suggest that feces are an important matrix in biomonitoring of exposure to environmental chemicals.
期刊介绍:
Environmental Science & Technology (ES&T) is a co-sponsored academic and technical magazine by the Hubei Provincial Environmental Protection Bureau and the Hubei Provincial Academy of Environmental Sciences.
Environmental Science & Technology (ES&T) holds the status of Chinese core journals, scientific papers source journals of China, Chinese Science Citation Database source journals, and Chinese Academic Journal Comprehensive Evaluation Database source journals. This publication focuses on the academic field of environmental protection, featuring articles related to environmental protection and technical advancements.