The role of the gut microbiome in modulating immunotherapy efficacy in colorectal cancer

IF 3.7 3区 生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY
IUBMB Life Pub Date : 2024-08-12 DOI:10.1002/iub.2908
Siyuan Zuo, Yong Huang, Junwei Zou
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引用次数: 0

Abstract

This systematic literature review and meta-analysis provide an overview of the critical role of gut microbiota in modulating the efficacy of immunotherapy for colorectal cancer. Gut microbes influence host immune responses through multiple mechanisms including modulation of immune cell activity, metabolite action, and immune tolerance. The ability of specific gut microbes to improve the efficacy of immune checkpoint inhibitors has been linked to their ability to improve gut barrier function, modulate immune cell activity, and produce key immunomodulatory metabolites such as short-chain fatty acids. In addition, the composition and diversity of the gut microbiota are strongly associated with the efficacy of immunotherapies, demonstrating the potential to improve therapeutic response by modifying the gut microbiota. This paper also discusses the prospect of manipulating the gut microbiota through strategies such as fecal microbial transplantation, probiotic supplementation, and dietary modifications to optimize the efficacy of immunotherapy.

肠道微生物组在调节结直肠癌免疫疗法疗效中的作用。
这篇系统性文献综述和荟萃分析概述了肠道微生物群在调节结直肠癌免疫疗法疗效方面的关键作用。肠道微生物通过多种机制影响宿主免疫反应,包括调节免疫细胞活性、代谢产物作用和免疫耐受。特定肠道微生物提高免疫检查点抑制剂疗效的能力与它们改善肠道屏障功能、调节免疫细胞活性和产生短链脂肪酸等关键免疫调节代谢物的能力有关。此外,肠道微生物群的组成和多样性与免疫疗法的疗效密切相关,这表明通过改变肠道微生物群有可能改善治疗反应。本文还讨论了通过粪便微生物移植、补充益生菌和调整饮食等策略操纵肠道微生物群以优化免疫疗法疗效的前景。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
IUBMB Life
IUBMB Life 生物-生化与分子生物学
CiteScore
10.60
自引率
0.00%
发文量
109
审稿时长
4-8 weeks
期刊介绍: IUBMB Life is the flagship journal of the International Union of Biochemistry and Molecular Biology and is devoted to the rapid publication of the most novel and significant original research articles, reviews, and hypotheses in the broadly defined fields of biochemistry, molecular biology, cell biology, and molecular medicine.
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