The role and therapeutic strategies for tissue-resident memory T cells, central memory T cells, and effector memory T cells in psoriasis

IF 4.9 3区医学 Q2 IMMUNOLOGY

Immunology Pub Date : 2024-08-13 DOI:10.1111/imm.13843

Guoshu Deng, Yulin Zhang, Jiankun Song, Ying Zhang, Qi Zheng, Yue Luo, Xiaoya Fei, Yang Yang, Le Kuai, Bin Li, Ying Luo

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引用次数: 0

Abstract

Psoriasis is a skin disease that is inflammatory and persistent, causing a high rate of recurrence, poor quality of life, and significant socioeconomic burden. Its main pathological manifestations are abnormal activation and infiltration of T cells and excessive proliferation of keratinocytes (KCs). The great majority of patients with psoriasis will relapse after remission. It usually lasts a lifetime and necessitates long-term treatment strategies. During periods of activity and remission, one of the main cell types in psoriasis is memory T cells, which include tissue-resident memory T (TRM) cells, central memory T (TCM) cells, and effector memory T (TEM) cells. They work by releasing inflammatory factors, cytotoxic particles, or altering cell subpopulations, leading to increased inflammation or recurrence. This review summarizes the role of memory T cells in the pathology and treatment of psoriasis, with a view to potential novel therapies and therapeutic targets.

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组织驻留记忆 T 细胞、中枢记忆 T 细胞和效应记忆 T 细胞在银屑病中的作用和治疗策略。

银屑病是一种炎症性皮肤病，具有顽固性，复发率高、生活质量差、社会经济负担重。其主要病理表现为 T 细胞的异常激活和浸润以及角质形成细胞（KC）的过度增殖。绝大多数银屑病患者在病情缓解后会复发。银屑病通常会持续终生，因此必须采取长期治疗策略。在银屑病的活动期和缓解期，记忆 T 细胞是银屑病的主要细胞类型之一，包括组织驻留记忆 T 细胞（TRM）、中心记忆 T 细胞（TCM）和效应记忆 T 细胞（TEM）。它们通过释放炎症因子、细胞毒性颗粒或改变细胞亚群发挥作用，导致炎症加重或复发。本综述总结了记忆 T 细胞在银屑病病理和治疗中的作用，并展望了潜在的新型疗法和治疗靶点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Immunology 医学-免疫学

CiteScore

11.90

自引率

1.60%

发文量

175

审稿时长

4-8 weeks

期刊介绍： Immunology is one of the longest-established immunology journals and is recognised as one of the leading journals in its field. We have global representation in authors, editors and reviewers. Immunology publishes papers describing original findings in all areas of cellular and molecular immunology. High-quality original articles describing mechanistic insights into fundamental aspects of the immune system are welcome. Topics of interest to the journal include: immune cell development, cancer immunology, systems immunology/omics and informatics, inflammation, immunometabolism, immunology of infection, microbiota and immunity, mucosal immunology, and neuroimmunology. The journal also publishes commissioned review articles on subjects of topical interest to immunologists, and commissions in-depth review series: themed sets of review articles which take a 360° view of select topics at the heart of immunological research.