Investigation of genetic markers associated to type 2 diabetes mellitus in Santarém-Pará.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-08-05 eCollection Date: 2024-01-01 DOI:10.1590/1678-4685-GMB-2023-0107

Adjanny Estela Santos de Souza, Caio Henrique Silva da Silva, Rita de Cássia Silva de Oliveira, Ana Paula Araújo Guimarães, Aylla Núbia Lima Martins da Silva, Isabela Guerreiro Diniz, Haiala Soter Silva de Oliveira, Diego Sarmento de Sousa, Fernanda Andreza de Pinho Lott Figueiredo, Greice de Lemos Cardoso Costa, João Farias Guerreiro

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Abstract

Genetic, epigenetic and environmental factors play an important role in the genesis of Type 2 Diabetes Mellitus (T2D). In the genetic context, one of the strategies used to investigate possible associations with diabetes is the search for Single Nucleotide Polymorphisms (SNPs), involving the comparison of alelle frequencies, the phenotypic variations and other relevant factors, such as environmental influences and lifestyle choices, Thus, the aim of this study was to find the relationship of risk variants for T2D in SNPs (rs4994) in the ADRB3 gene; (rs1799854) in the ABCC8 gene; (rs7901695 and rs12255372) in the TCF7L2 gene; and (rs8050136) in the FTO gene in a sample of the population of the municipality of Santarém (PA), Brazilian Amazon, in the northern region of Brazil. ABCC8 (rs1799854 C>T) showed a statistically significant association with T2D. Each chosen gene and SNP has been previously implicated in T2D risk according to existing scientific literature, owing to their roles in glucose regulation and body fat.

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对圣塔伦-帕拉州 2 型糖尿病相关遗传标记的调查。

遗传、表观遗传和环境因素在 2 型糖尿病（T2D）的发病过程中起着重要作用。在遗传学方面，用于研究与糖尿病可能存在的关联的策略之一是寻找单核苷酸多态性（SNPs），其中包括比较单核苷酸频率、表型变异和其他相关因素，如环境影响和生活方式选择；(rs1799854) 、ABCC8 基因中的 SNPs (rs7901695 和 rs12255372) 和 FTO 基因中的 SNPs (rs8050136) 与 T2D 的关系。ABCC8（rs1799854 C>T）与 T2D 有显著的统计学关联。根据现有的科学文献，所选的每个基因和 SNP 以前都与 T2D 风险有关，因为它们在葡萄糖调节和体内脂肪方面发挥作用。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.