Electrographic seizures during low-current thalamic deep brain stimulation in mice

IF 7.6 1区医学 Q1 CLINICAL NEUROLOGY

Brain Stimulation Pub Date : 2024-08-10 DOI:10.1016/j.brs.2024.08.002

Francisco J. Flores , Isabella Dalla Betta , John Tauber , David R. Schreier , Emily P. Stephen , Matthew A. Wilson , Emery N. Brown

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引用次数: 0

Abstract

Background:

Deep brain stimulation of the central thalamus (CT-DBS) has potential for modulating states of consciousness, but it can also trigger electrographic seizures, including poly-spike-wave trains (PSWT).

Objectives:

To report the probability of inducing PSWTs during CT-DBS in awake, freely-moving mice.

Methods:

Mice were implanted with electrodes to deliver unilateral and bilateral CT-DBS at different frequencies while recording electroencephalogram (EEG). We titrated stimulation current by gradually increasing it at each frequency until a PSWT appeared. Subsequent stimulations to test arousal modulation were performed at the current one step below the current that caused a PSWT during titration.

Results:

In 2.21% of the test stimulations (10 out of 12 mice), CT-DBS caused PSWTs at currents lower than the titrated current, including currents as low as 20 $μ$ A.

Conclusion:

Our study found a small but significant probability of inducing PSWTs even after titration and at relatively low currents. EEG should be closely monitored for electrographic seizures when performing CT-DBS in both research and clinical settings.

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小鼠丘脑深部低电流刺激时的电图癫痫发作。

背景：丘脑中枢深部脑刺激（CT-DBS）具有调节意识状态的潜力，但也可能引发电图癫痫发作，包括多棘波序列（PSWT）：目的：报告在清醒、自由活动的小鼠体内进行 CT-DBS 时诱发 PSWT 的概率：给小鼠植入电极，以不同频率进行单侧和双侧 CT-DBS，同时记录脑电图。我们通过逐渐增加每个频率的刺激电流进行滴定，直到出现 PSWT。测试唤醒调节的后续刺激是在比滴定时引起 PSWT 的电流低一级的电流下进行的：在 2.21% 的测试刺激中（12 只小鼠中的 10 只），CT-DBS 在低于滴定电流的电流下引起 PSWT，最低电流为 20 μA：我们的研究发现，即使在滴定后和相对较低的电流下，诱发 PSWT 的概率也很小，但意义重大。在研究和临床环境中进行 CT-DBS 时，应密切监测脑电图，以防电图性癫痫发作。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Brain Stimulation 医学-临床神经学

CiteScore

13.10

自引率

9.10%

发文量

256

审稿时长

72 days

期刊介绍： Brain Stimulation publishes on the entire field of brain stimulation, including noninvasive and invasive techniques and technologies that alter brain function through the use of electrical, magnetic, radiowave, or focally targeted pharmacologic stimulation. Brain Stimulation aims to be the premier journal for publication of original research in the field of neuromodulation. The journal includes: a) Original articles; b) Short Communications; c) Invited and original reviews; d) Technology and methodological perspectives (reviews of new devices, description of new methods, etc.); and e) Letters to the Editor. Special issues of the journal will be considered based on scientific merit.