The risk of thyroid cancer and sex differences in Hashimoto's thyroiditis, a meta-analysis.

IF 2.8 3区医学 Q3 ENDOCRINOLOGY & METABOLISM

BMC Endocrine Disorders Pub Date : 2024-08-13 DOI:10.1186/s12902-024-01670-w

Yali Le, Chenchen Geng, Xiaoqian Gao, Ping Zhang

{"title":"The risk of thyroid cancer and sex differences in Hashimoto's thyroiditis, a meta-analysis.","authors":"Yali Le, Chenchen Geng, Xiaoqian Gao, Ping Zhang","doi":"10.1186/s12902-024-01670-w","DOIUrl":null,"url":null,"abstract":"Background and objective: The prevalence of thyroid cancer (TC) has exhibited an upward trajectory in recent years. An accelerating amount of evidence shows a significant association between Hashimoto's thyroiditis (HT) and TC. The present study encompasses a meticulously designed systematic review and meta-analysis with the aim of scrutinizing the risk of TC and clarifying sex disparities in HT.Methods: A comprehensive search was conducted across reputable online databases, including PubMed, Cochrane Library, EMBASE, and Web of Science. English-language publications on the correlation between HT and TC were examined without temporal restrictions. Two authors independently screened the articles and extracted pertinent data. The collected data underwent statistical analysis using the STATA software, enabling the calculation of the pooled Odds Ratio (OR) and 95% confidence intervals (CI). Additionally, a supplementary analysis was conducted on studies incorporating sex-specific data to determine the OR (female vs. male) and the sex-based prevalence of TC in HT.Results: A total of 2,845 records were obtained, and 26 retrospective studies were included in this meta-analysis. The results indicated a significant role for HT in TC (OR: 2.22, 95% CI: 1.85-2.67). Supplementary analysis indicated that the prevalence of TC in HT patients was lower in women (0.31, 95% CI: 0.17-0.45) than in men (0.37, 95% CI: 0.21-0.53). However, the result was not statistically significant.Conclusion: This systematic review and meta-analysis provide evidence that HT is associated with increasing odds of TC. Regular review of HT patients holds positive clinical significance.","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":null,"pages":null},"PeriodicalIF":2.8000,"publicationDate":"2024-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11321178/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"BMC Endocrine Disorders","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1186/s12902-024-01670-w","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}

引用次数: 0

Abstract

Background and objective: The prevalence of thyroid cancer (TC) has exhibited an upward trajectory in recent years. An accelerating amount of evidence shows a significant association between Hashimoto's thyroiditis (HT) and TC. The present study encompasses a meticulously designed systematic review and meta-analysis with the aim of scrutinizing the risk of TC and clarifying sex disparities in HT.

Methods: A comprehensive search was conducted across reputable online databases, including PubMed, Cochrane Library, EMBASE, and Web of Science. English-language publications on the correlation between HT and TC were examined without temporal restrictions. Two authors independently screened the articles and extracted pertinent data. The collected data underwent statistical analysis using the STATA software, enabling the calculation of the pooled Odds Ratio (OR) and 95% confidence intervals (CI). Additionally, a supplementary analysis was conducted on studies incorporating sex-specific data to determine the OR (female vs. male) and the sex-based prevalence of TC in HT.

Results: A total of 2,845 records were obtained, and 26 retrospective studies were included in this meta-analysis. The results indicated a significant role for HT in TC (OR: 2.22, 95% CI: 1.85-2.67). Supplementary analysis indicated that the prevalence of TC in HT patients was lower in women (0.31, 95% CI: 0.17-0.45) than in men (0.37, 95% CI: 0.21-0.53). However, the result was not statistically significant.

Conclusion: This systematic review and meta-analysis provide evidence that HT is associated with increasing odds of TC. Regular review of HT patients holds positive clinical significance.

查看原文本刊更多论文

桥本氏甲状腺炎患者罹患甲状腺癌的风险和性别差异的荟萃分析。

背景和目的：近年来，甲状腺癌（TC）的发病率呈上升趋势。越来越多的证据表明，桥本氏甲状腺炎（HT）与甲状腺癌之间存在显著关联。本研究包括一项精心设计的系统综述和荟萃分析，旨在仔细研究桥本氏甲状腺炎的风险，并澄清桥本氏甲状腺炎的性别差异：在PubMed、Cochrane Library、EMBASE和Web of Science等著名在线数据库中进行了全面检索。对有关 HT 和 TC 之间相关性的英文出版物进行了研究，没有时间限制。两位作者独立筛选文章并提取相关数据。使用 STATA 软件对收集到的数据进行统计分析，计算汇总的比值比 (OR) 和 95% 置信区间 (CI)。此外，还对包含性别特异性数据的研究进行了补充分析，以确定HT中TC的OR（女性与男性）和基于性别的患病率：本次荟萃分析共获得 2,845 条记录，纳入了 26 项回顾性研究。结果表明，HT 对 TC 有显著影响（OR：2.22，95% CI：1.85-2.67）。补充分析表明，女性高血压患者的血脂增高率（0.31，95% CI：0.17-0.45）低于男性（0.37，95% CI：0.21-0.53）。然而，这一结果在统计学上并不显著：本系统综述和荟萃分析提供了 HT 与 TC 发生几率增加有关的证据。对高血压患者进行定期复查具有积极的临床意义。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

BMC Endocrine Disorders ENDOCRINOLOGY & METABOLISM-

CiteScore

4.40

自引率

0.00%

发文量

280

审稿时长

>12 weeks

期刊介绍： BMC Endocrine Disorders is an open access, peer-reviewed journal that considers articles on all aspects of the prevention, diagnosis and management of endocrine disorders, as well as related molecular genetics, pathophysiology, and epidemiology.

文献相关原料

公司名称	产品信息	采购帮参考价格