Satellite cell dynamics during skeletal muscle hypertrophy.

IF 3.8 3区 生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY
Tolulope P Saliu, Jensen Goh, Gyumin Kang, Benjamin I Burke, Ahmed Ismaeel, John J McCarthy
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引用次数: 0

Abstract

Skeletal muscle stem cells (MuSCs) display distinct behavior crucial for tissue maintenance and repair. Upon activation, MuSCs exhibit distinct modes of division: symmetric division, facilitating either self-renewal or differentiation, and asymmetric division, which dictates divergent cellular fates. This review explores the nuanced dynamics of MuSC division and the molecular mechanisms governing this behavior. Furthermore, it introduces a novel phenomenon observed in a subset of MuSCs under hypertrophic stimuli termed division-independent differentiation. Insights into the underlying mechanisms driving this process are discussed, alongside its broader implications for muscle physiology.

骨骼肌肥大过程中卫星细胞的动态变化
骨骼肌干细胞(MuSCs)表现出对组织维护和修复至关重要的独特行为。激活后,MuSCs 表现出不同的分裂模式:对称分裂促进自我更新或分化,而非对称分裂则决定不同的细胞命运。这篇综述探讨了MuSC分裂的微妙动态以及支配这种行为的分子机制。此外,它还介绍了在增生性刺激下观察到的一种新现象,即MuSCs亚群的独立分裂分化。文章讨论了驱动这一过程的内在机制,以及它对肌肉生理学的广泛影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Biochemical Society transactions
Biochemical Society transactions 生物-生化与分子生物学
CiteScore
7.80
自引率
0.00%
发文量
351
审稿时长
3-6 weeks
期刊介绍: Biochemical Society Transactions is the reviews journal of the Biochemical Society. Publishing concise reviews written by experts in the field, providing a timely snapshot of the latest developments across all areas of the molecular and cellular biosciences. Elevating our authors’ ideas and expertise, each review includes a perspectives section where authors offer comment on the latest advances, a glimpse of future challenges and highlighting the importance of associated research areas in far broader contexts.
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