Alpha tACS Improves Cognition and Modulates Neurotransmission in Dementia with Lewy Bodies

IF 7.4 1区医学 Q1 CLINICAL NEUROLOGY

Movement Disorders Pub Date : 2024-08-13 DOI:10.1002/mds.29969

Alberto Benussi MD, Valentina Cantoni PhD, Jasmine Rivolta MSc, Nicola Zoppi MD, Maria Sofia Cotelli MD, Marta Bianchi MD, Maria Cotelli PhD, Barbara Borroni MD

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Abstract

Background

Dementia with Lewy bodies (DLB) is characterized by a marked shift of electroencephalographic (EEG) power and dominant rhythm, from the α toward the θ frequency range. Transcranial alternate current stimulation (tACS) is a non-invasive brain stimulation technique that allows entrainment of cerebral oscillations at desired frequencies.

Objectives

Our goal is to evaluate the effects of occipital α-tACS on cognitive functions and neurophysiological measures in patients with DLB.

Methods

We conducted a double-blind, randomized, sham-controlled, cross-over clinical trial in 14 participants with DLB. Participants were randomized to receive either α-tACS (60 minutes of 3 mA peak-to-peak stimulation at 12 Hz) or sham stimulation applied over the occipital cortex. Clinical evaluations were performed to assess visuospatial and executive functions, as well as verbal episodic memory. Neurophysiological assessments and EEG recordings were conducted at baseline and following both α-tACS and sham stimulations.

Results

Occipital α-tACS was safe and well-tolerated. We observed a significant enhancement in visuospatial abilities and executive functions, but no improvement in verbal episodic memory. We observed an increase in short latency afferent inhibition, a neurophysiological marker indirectly and partially dependent on cholinergic transmission, coinciding with an increase in α power and a decrease in Δ power following α-tACS stimulation, effects not seen with sham stimulation.

Conclusions

This study demonstrates that occipital α-tACS is safe and enhances visuospatial and executive functions in patients with DLB. Improvements in indirect markers of cholinergic transmission and EEG changes indicate significant neurophysiological engagement. These findings justify further exploration of α-tACS as a therapeutic option for DLB patients. © 2024 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.

Abstract Image

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α-tACS可改善路易体痴呆症患者的认知能力并调节神经传导。

背景：路易体痴呆症（DLB）的特征是脑电图（EEG）功率和主要节律从α频率范围向θ频率范围明显转移。经颅交替电流刺激（tACS）是一种非侵入性脑刺激技术，可将脑振荡控制在所需频率：我们的目标是评估枕部 α-tACS 对 DLB 患者认知功能和神经电生理指标的影响：我们对 14 名 DLB 患者进行了双盲、随机、假对照、交叉临床试验。参与者被随机分配接受α-tACS（60 分钟 3 毫安、12 赫兹的峰峰值刺激）或枕叶皮层假刺激。临床评估用于评估视觉空间功能、执行功能以及言语表象记忆。在α-tACS和假刺激的基线期和之后进行了神经生理学评估和脑电图记录：结果：枕叶α-tACS安全且耐受性良好。我们观察到视觉空间能力和执行功能明显增强，但言语外显记忆没有改善。我们观察到，α-tACS刺激后，短潜伏期传入抑制（一种间接和部分依赖于胆碱能传导的神经生理标志物）增加，同时α功率增加，Δ功率下降，而假刺激则没有这种效果：这项研究表明，枕部α-tACS是安全的，并能增强DLB患者的视觉空间功能和执行功能。胆碱能传递间接标记物的改善和脑电图的变化表明，神经生理学参与显著。这些发现证明，α-tACS 作为 DLB 患者的一种治疗选择值得进一步探索。© 2024 作者姓名运动障碍》由 Wiley Periodicals LLC 代表国际帕金森和运动障碍协会出版。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Movement Disorders 医学-临床神经学

CiteScore

13.30

自引率

8.10%

发文量

371

审稿时长

12 months

期刊介绍： Movement Disorders publishes a variety of content types including Reviews, Viewpoints, Full Length Articles, Historical Reports, Brief Reports, and Letters. The journal considers original manuscripts on topics related to the diagnosis, therapeutics, pharmacology, biochemistry, physiology, etiology, genetics, and epidemiology of movement disorders. Appropriate topics include Parkinsonism, Chorea, Tremors, Dystonia, Myoclonus, Tics, Tardive Dyskinesia, Spasticity, and Ataxia.