{"title":"Characterization and Pathogenicity of Novel Reassortment H6N6 Avian Influenza Viruses in Southern China","authors":"Puduo Zhu, Xudong He, Yiquan Chen, Zhuanqiang Yan, Qunhui Li, Qi Zhou, Wencheng Lin, Feng Chen","doi":"10.1155/2024/4005909","DOIUrl":null,"url":null,"abstract":"<div>\n <p>The H6N6 avian influenza virus (AIV) subtype is one of the most frequently isolated subtypes in poultry, and it has a broad host range. Some strains can overcome species barriers for transmission and infect humans. Increased affinity for human-type receptors is a key factor in this process. In this study, two H6N6 AIV strains originating from five different clades, in which amino acid 226 of hemagglutinin was mutated from glutamine to lysine, were isolated from ducks. The receptor-binding preference and pathogenicity of the two strains in poultry and mice were evaluated. The results indicated that the DK/GD/W3 strain can bind to both <i>α</i>-2,6 and <i>α</i>-2,3 receptors, whereas the DK/GD/L31 strain maintained affinity toward avian-origin <i>α</i>-2,3 receptors, highlighting differences in receptor tropism and pathogenicity to different hosts for two H6N6 strains with the same genetic background. These findings have revealed the complex recombination characteristics and molecular characteristics of H6N6 circulating strains in the environment and underscored the importance of continuous surveillance of this subtype for livestock and poultry health as well as human safety.</p>\n </div>","PeriodicalId":234,"journal":{"name":"Transboundary and Emerging Diseases","volume":"2024 1","pages":""},"PeriodicalIF":3.5000,"publicationDate":"2024-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/2024/4005909","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Transboundary and Emerging Diseases","FirstCategoryId":"97","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1155/2024/4005909","RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"INFECTIOUS DISEASES","Score":null,"Total":0}
引用次数: 0
Abstract
The H6N6 avian influenza virus (AIV) subtype is one of the most frequently isolated subtypes in poultry, and it has a broad host range. Some strains can overcome species barriers for transmission and infect humans. Increased affinity for human-type receptors is a key factor in this process. In this study, two H6N6 AIV strains originating from five different clades, in which amino acid 226 of hemagglutinin was mutated from glutamine to lysine, were isolated from ducks. The receptor-binding preference and pathogenicity of the two strains in poultry and mice were evaluated. The results indicated that the DK/GD/W3 strain can bind to both α-2,6 and α-2,3 receptors, whereas the DK/GD/L31 strain maintained affinity toward avian-origin α-2,3 receptors, highlighting differences in receptor tropism and pathogenicity to different hosts for two H6N6 strains with the same genetic background. These findings have revealed the complex recombination characteristics and molecular characteristics of H6N6 circulating strains in the environment and underscored the importance of continuous surveillance of this subtype for livestock and poultry health as well as human safety.
期刊介绍：
Transboundary and Emerging Diseases brings together in one place the latest research on infectious diseases considered to hold the greatest economic threat to animals and humans worldwide. The journal provides a venue for global research on their diagnosis, prevention and management, and for papers on public health, pathogenesis, epidemiology, statistical modeling, diagnostics, biosecurity issues, genomics, vaccine development and rapid communication of new outbreaks. Papers should include timely research approaches using state-of-the-art technologies. The editors encourage papers adopting a science-based approach on socio-economic and environmental factors influencing the management of the bio-security threat posed by these diseases, including risk analysis and disease spread modeling. Preference will be given to communications focusing on novel science-based approaches to controlling transboundary and emerging diseases. The following topics are generally considered out-of-scope, but decisions are made on a case-by-case basis (for example, studies on cryptic wildlife populations, and those on potential species extinctions):
Pathogen discovery: a common pathogen newly recognised in a specific country, or a new pathogen or genetic sequence for which there is little context about — or insights regarding — its emergence or spread.
Prevalence estimation surveys and risk factor studies based on survey (rather than longitudinal) methodology, except when such studies are unique. Surveys of knowledge, attitudes and practices are within scope.
Diagnostic test development if not accompanied by robust sensitivity and specificity estimation from field studies.
Studies focused only on laboratory methods in which relevance to disease emergence and spread is not obvious or can not be inferred (“pure research” type studies).
Narrative literature reviews which do not generate new knowledge. Systematic and scoping reviews, and meta-analyses are within scope.
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