Dietary Networks Identified by Gaussian Graphical Model and Odds of Major Depressive Disorder: A Case-Control Study

IF 2.2 4区 医学 Q2 MEDICINE, GENERAL & INTERNAL
Hossein Shahinfar, Sakineh Shab-Bidar, Mohammad Effatpanah, Reza Askari, Shima Jazayeri
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引用次数: 0

Abstract

Background. The Gaussian graphical model (GGM) is a new approach that has recently gained attention for identifying dietary patterns. It examines the connections between different food groups and how they are consumed together. The aim of our study was to investigate the link between dietary networks derived from GGM and the odds of major depressive disorder (MDD). Methods. Two hundred drug-free patients with MDD and 200 healthy individuals were enrolled in this age- and sex-matched case-control study. The mean age of the participants was 45.4 years and 67.5% were female. The Beck Depression Inventory-II questionnaire was used for screening depression in the control group. Dietary intake was assessed using a 168-item food frequency questionnaire A GGM was applied to identify dietary networks. The GGM-derived networks were scored, categorized into tertiles, and their association with MDD was determined using a multivariable logistic regression model controlling for energy intake, marital status, job status, income, living status, education, drug use, smoking status, physical activity level, family history of major depressive disorders, comorbidities, and BMI. Results. GGM identified four dietary networks: healthy, prudent, western, and mixed. Nonleafy vegetables in healthy, grains in prudent, and red meat in western dietary networks were identified as hubs, indicating their important position in the identified network. High adherence to a healthy dietary network was associated with decreased odds of MDD (OR: 0.54, 95% CI: 0.31, 0.92; p value = 0.02), whereas, participants at the highest tertile of the western dietary network had greater odds of MDD (OR: 1.80, 95% CI: 1.05, 3.08; p value = 0.03). Neither prudent nor mixed networks were associated with MDD. Conclusions. Healthy and western dietary networks were associated with lower and higher odds of MDD, respectively. Recommendations for reducing the odds of MDD can be focused on increasing nonleafy vegetables and decreasing red meat consumption.

Abstract Image

高斯图形模型识别的膳食网络与重度抑郁障碍的几率:病例对照研究
背景。高斯图形模型(GGM)是一种新方法,最近在确定膳食模式方面受到关注。它研究了不同食物组之间的联系以及它们是如何一起消费的。我们的研究旨在调查从高斯图模型中得出的膳食网络与重度抑郁障碍(MDD)发生几率之间的联系。研究方法这项年龄和性别匹配的病例对照研究招募了 200 名未服药的重度抑郁症患者和 200 名健康人。参与者的平均年龄为 45.4 岁,67.5% 为女性。对照组采用贝克抑郁量表-II问卷进行抑郁筛查。采用 168 项食物频率问卷对饮食摄入量进行评估。采用多变量逻辑回归模型对 GGM 衍生的膳食网络进行评分,并将其分为三等分,确定其与 MDD 的关系,该模型控制了能量摄入、婚姻状况、工作状况、收入、生活状况、教育程度、药物使用、吸烟状况、体力活动水平、重度抑郁症家族史、合并症和体重指数。研究结果GGM 确定了四种膳食网络:健康型、谨慎型、西方型和混合型。健康膳食网络中的非叶菜类蔬菜、谨慎膳食网络中的谷物和西方膳食网络中的红肉被确定为枢纽,表明它们在所确定的网络中处于重要位置。对健康膳食网络的高度坚持与 MDD 发生几率的降低有关(OR:0.54,95% CI:0.31,0.92;P 值 = 0.02),而处于西方膳食网络最高层的参与者发生 MDD 的几率更高(OR:1.80,95% CI:1.05,3.08;P 值 = 0.03)。谨慎饮食网络和混合饮食网络均与 MDD 无关。结论健康饮食网络和西方饮食网络分别与较低和较高的 MDD 发生几率有关。降低多发性硬化症几率的建议可侧重于增加非叶菜类蔬菜的摄入量和减少红肉的摄入量。
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来源期刊
CiteScore
5.30
自引率
0.00%
发文量
274
审稿时长
3-8 weeks
期刊介绍: IJCP is a general medical journal. IJCP gives special priority to work that has international appeal. IJCP publishes: Editorials. IJCP Editorials are commissioned. [Peer reviewed at the editor''s discretion] Perspectives. Most IJCP Perspectives are commissioned. Example. [Peer reviewed at the editor''s discretion] Study design and interpretation. Example. [Always peer reviewed] Original data from clinical investigations. In particular: Primary research papers from RCTs, observational studies, epidemiological studies; pre-specified sub-analyses; pooled analyses. [Always peer reviewed] Meta-analyses. [Always peer reviewed] Systematic reviews. From October 2009, special priority will be given to systematic reviews. [Always peer reviewed] Non-systematic/narrative reviews. From October 2009, reviews that are not systematic will be considered only if they include a discrete Methods section that must explicitly describe the authors'' approach. Special priority will, however, be given to systematic reviews. [Always peer reviewed] ''How to…'' papers. Example. [Always peer reviewed] Consensus statements. [Always peer reviewed] Short reports. [Always peer reviewed] Letters. [Peer reviewed at the editor''s discretion] International scope IJCP publishes work from investigators globally. Around 30% of IJCP articles list an author from the UK. Around 30% of IJCP articles list an author from the USA or Canada. Around 45% of IJCP articles list an author from a European country that is not the UK. Around 15% of articles published in IJCP list an author from a country in the Asia-Pacific region.
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