IL10 and CXCL10 mRNA expression in food protein–induced enterocolitis syndrome

IF 3.7 3区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Cytokine Pub Date : 2024-08-11 DOI:10.1016/j.cyto.2024.156720

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引用次数: 0

Abstract

Background

Food protein-induced enterocolitis syndrome (FPIES) is a rare non-IgE-mediated food allergy that mainly impacts babies and 7toddlers. The exact mechanism of FPIES is not completely understood. By studying the expression of IL-10 and CXCL10 in pediatric FPIES patients, researchers can gain insights into the immune mechanisms underlying this disorder.

Methods

Peripheral venous blood was collected and subsequently stabilized with RNA pro. Total RNA was extracted and mRNA levels of CXCL10 and IL-10 was determined with real time PCR.

Results

Children with FPIES had significantly higher values than the healthy control group (HC) for CXCL10 while FPIES had a significant lower values than the control group for IL-10.

Conclusions

Our results show a high production of CXCL10 and a concomitant reduced production of IL-10 in FPIES subjects who have not yet reached tolerance. These data may represent a molecular diagnostic marker for FPIES.

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食物蛋白诱发的小肠结肠炎综合征中 IL10 和 CXCL10 mRNA 的表达

背景食物蛋白诱发小肠结肠炎综合征（FPIES）是一种罕见的非 IgE 介导的食物过敏症，主要影响婴幼儿。FPIES的确切机制尚不完全清楚。通过研究小儿 FPIES 患者体内 IL-10 和 CXCL10 的表达，研究人员可以深入了解这种疾病的免疫机制。结果显示，FPIES 患儿的 CXCL10 含量明显高于健康对照组（HC），而 FPIES 患儿的 IL-10 含量则明显低于对照组。这些数据可能是 FPIES 的分子诊断标志物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cytokine 医学-免疫学

CiteScore

7.60

自引率

2.60%

发文量

262

审稿时长

48 days

期刊介绍： The journal Cytokine has an open access mirror journal Cytokine: X, sharing the same aims and scope, editorial team, submission system and rigorous peer review. * Devoted exclusively to the study of the molecular biology, genetics, biochemistry, immunology, genome-wide association studies, pathobiology, diagnostic and clinical applications of all known interleukins, hematopoietic factors, growth factors, cytotoxins, interferons, new cytokines, and chemokines, Cytokine provides comprehensive coverage of cytokines and their mechanisms of actions, 12 times a year by publishing original high quality refereed scientific papers from prominent investigators in both the academic and industrial sectors. We will publish 3 major types of manuscripts: 1) Original manuscripts describing research results. 2) Basic and clinical reviews describing cytokine actions and regulation. 3) Short commentaries/perspectives on recently published aspects of cytokines, pathogenesis and clinical results.