Utilizing omics technologies in the investigation of sepsis-induced cardiomyopathy

IF 2.5 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

IJC Heart and Vasculature Pub Date : 2024-07-30 DOI:10.1016/j.ijcha.2024.101477

引用次数: 0

Abstract

Sepsis-induced cardiomyopathy (SIC) is a common and high-mortality complication among critically ill patients. Uncertainties persist regarding the pathogenesis, pathophysiology, and diagnosis of SIC, underscoring the necessity to investigate potential biological mechanisms. With the rise of omics technologies, leveraging their high throughput and big data advantages, a systems biology perspective is employed to study the biological processes of SIC. This approach aids in gaining a better understanding of the disease’s onset, progression, and outcomes, ultimately providing improved guidance for clinical practices. This review summarizes the currently applied omics technologies, omics studies related to SIC, and relevant omics databases.

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利用全息技术研究脓毒症诱发的心肌病

脓毒症诱发的心肌病（SIC）是重症患者中常见的并发症，死亡率很高。SIC的发病机制、病理生理学和诊断仍存在不确定性，这凸显了研究潜在生物机制的必要性。随着 omics 技术的兴起，利用其高通量和大数据的优势，采用系统生物学的观点来研究 SIC 的生物学过程。这种方法有助于更好地了解疾病的发病、进展和结果，最终为临床实践提供更好的指导。本综述总结了目前应用的 omics 技术、与 SIC 相关的 omics 研究以及相关的 omics 数据库。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

IJC Heart and Vasculature Medicine-Cardiology and Cardiovascular Medicine

CiteScore

4.90

自引率

10.30%

发文量

216

审稿时长

56 days

期刊介绍： IJC Heart & Vasculature is an online-only, open-access journal dedicated to publishing original articles and reviews (also Editorials and Letters to the Editor) which report on structural and functional cardiovascular pathology, with an emphasis on imaging and disease pathophysiology. Articles must be authentic, educational, clinically relevant, and original in their content and scientific approach. IJC Heart & Vasculature requires the highest standards of scientific integrity in order to promote reliable, reproducible and verifiable research findings. All authors are advised to consult the Principles of Ethical Publishing in the International Journal of Cardiology before submitting a manuscript. Submission of a manuscript to this journal gives the publisher the right to publish that paper if it is accepted. Manuscripts may be edited to improve clarity and expression.