Oxytocin pathway gene variation and corticostriatal resting-state functional connectivity

IF 2.1 Q3 ENDOCRINOLOGY & METABOLISM

Comprehensive psychoneuroendocrinology Pub Date : 2024-07-31 DOI:10.1016/j.cpnec.2024.100255

Shanshan Xiao , Håkan Fischer , Natalie C. Ebner , Gull Rukh , Junhua Dang , Lars Westberg , Helgi B. Schiöth

{"title":"Oxytocin pathway gene variation and corticostriatal resting-state functional connectivity","authors":"Shanshan Xiao , Håkan Fischer , Natalie C. Ebner , Gull Rukh , Junhua Dang , Lars Westberg , Helgi B. Schiöth","doi":"10.1016/j.cpnec.2024.100255","DOIUrl":null,"url":null,"abstract":"<div><p>Genetic variations in single nucleotide polymorphisms (SNPs) within oxytocin pathway genes have been linked to social behavior and neurodevelopmental conditions. However, the neurobiological mechanisms underlying these associations remain elusive. In this study, we investigated the relationship between variations of 10 SNPs in oxytocin pathway genes and resting-state functional connectivity among 55 independent components using a large sample from the UK Biobank (N ≈ 30,000). Our findings revealed that individuals with the GG genotype at rs4813627 within the oxytocin structural gene (<em>OXT</em>) exhibited weaker resting-state functional connectivity in the corticostriatal circuit compared to those with the GA/AA genotypes. Empirical evidence has linked the GG genotype at <em>OXT</em> rs4813627 with a behavioral tendency of insensitivity to others. These results inform the neural mechanisms by which oxytocin-related genetic factors can influence social behavior.</p></div>","PeriodicalId":72656,"journal":{"name":"Comprehensive psychoneuroendocrinology","volume":"20 ","pages":"Article 100255"},"PeriodicalIF":2.1000,"publicationDate":"2024-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666497624000316/pdfft?md5=82d4fd83392d030f6e3314ad93212a34&pid=1-s2.0-S2666497624000316-main.pdf","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Comprehensive psychoneuroendocrinology","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2666497624000316","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}

引用次数: 0

Abstract

Genetic variations in single nucleotide polymorphisms (SNPs) within oxytocin pathway genes have been linked to social behavior and neurodevelopmental conditions. However, the neurobiological mechanisms underlying these associations remain elusive. In this study, we investigated the relationship between variations of 10 SNPs in oxytocin pathway genes and resting-state functional connectivity among 55 independent components using a large sample from the UK Biobank (N ≈ 30,000). Our findings revealed that individuals with the GG genotype at rs4813627 within the oxytocin structural gene (OXT) exhibited weaker resting-state functional connectivity in the corticostriatal circuit compared to those with the GA/AA genotypes. Empirical evidence has linked the GG genotype at OXT rs4813627 with a behavioral tendency of insensitivity to others. These results inform the neural mechanisms by which oxytocin-related genetic factors can influence social behavior.

查看原文本刊更多论文

催产素通路基因变异与皮层静息态功能连通性

催产素通路基因中单核苷酸多态性（SNPs）的遗传变异与社会行为和神经发育状况有关。然而，这些关联背后的神经生物学机制仍然难以捉摸。在这项研究中，我们利用英国生物库（UK Biobank）的大样本（N ≈ 30,000）调查了催产素通路基因中 10 个 SNPs 的变异与 55 个独立成分的静息态功能连接之间的关系。我们的研究结果表明，催产素结构基因（OXT）rs4813627的GG基因型个体与GA/AA基因型个体相比，在皮层神经回路中表现出较弱的静息状态功能连通性。经验证据表明，OXT rs4813627 的 GG 基因型与对他人不敏感的行为倾向有关。这些结果为催产素相关遗传因素影响社会行为的神经机制提供了信息。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊