Unsymmetrical cationic porphyrin that forms sedimentation-unstable complexes with nucleic acids

IF 1.8 4区化学 Q3 CHEMISTRY, MULTIDISCIPLINARY

Mendeleev Communications Pub Date : 2024-07-01 DOI:10.1016/j.mencom.2024.06.018

引用次数: 0

Abstract

A water-soluble cationic porphyrin containing N-methyl- pyridinium fragments and an indole residue, namely, 5-[4-(1-methylindol-2-yl)phenyl]-10,15,20-tris(1-methyl- pyridinium-3-yl)porphyrin triiodide, has been synthesized. The porphyrin forms sedimentation unstable complexes with low and high molecular weight nucleic acids. This ability to precipitate nucleic acids can be used in laboratory, clinical and research practice for isolating nucleic acids.

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与核酸形成沉降不稳定复合物的不对称阳离子卟啉

我们合成了一种含有 N-甲基吡啶鎓片段和吲哚残基的水溶性阳离子卟啉，即 5-[4-(1-甲基吲哚-2-基)苯基]-10,15,20-三(1-甲基吡啶鎓-3-基)卟啉三碘化物。这种卟啉与低分子量和高分子量的核酸形成沉淀不稳定的复合物。这种沉淀核酸的能力可用于实验室、临床和研究实践中分离核酸。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Mendeleev Communications 化学-化学综合

CiteScore

3.00

自引率

21.10%

发文量

226

审稿时长

4-8 weeks

期刊介绍： Mendeleev Communications is the journal of the Russian Academy of Sciences, launched jointly by the Academy of Sciences of the USSR and the Royal Society of Chemistry (United Kingdom) in 1991. Starting from 1st January 2007, Elsevier is the new publishing partner of Mendeleev Communications. Mendeleev Communications publishes short communications in chemistry. The journal primarily features papers from the Russian Federation and the other states of the former USSR. However, it also includes papers by authors from other parts of the world. Mendeleev Communications is not a translated journal, but instead is published directly in English. The International Editorial Board is composed of eminent scientists who provide advice on refereeing policy.

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