Integrating Neuroprotective and Anti-inflammatory Strategies in the Development of PI3K Inhibitors for Enhanced Cancer Therapy

IF 4 3区医学 Q2 CHEMISTRY, MEDICINAL

ACS Medicinal Chemistry Letters Pub Date : 2024-07-25 DOI:10.1021/acsmedchemlett.4c0032710.1021/acsmedchemlett.4c00327

Robert B. Kargbo*,

引用次数: 0

Abstract

The inhibition of phosphoinositide 3-kinases (PI3Ks) is a promising approach in cancer therapy due to their critical role in cellular growth, proliferation, and survival. This Patent Highlight explores the mechanism of action of novel PI3K inhibitors, emphasizing their efficacy in targeting various PI3K isoforms. The work integrates neuroprotective and anti-inflammatory strategies from related patents, highlighting their potential to enhance the therapeutic profile of these inhibitors. It also considers advanced diagnostic methods for monitoring treatment efficacy and safety, underscoring the need for a comprehensive approach to cancer treatment.

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在开发 PI3K 抑制剂以加强癌症治疗的过程中整合神经保护和抗炎策略

由于磷酸肌酸 3- 激酶 (PI3K) 在细胞生长、增殖和存活中起着关键作用，因此抑制 PI3K 是一种很有前景的癌症治疗方法。本专利摘要探讨了新型 PI3K 抑制剂的作用机制，强调了它们针对各种 PI3K 同工酶的功效。这项工作整合了相关专利中的神经保护和抗炎策略，强调了它们增强这些抑制剂治疗效果的潜力。它还考虑了监测治疗效果和安全性的先进诊断方法，强调了采用综合方法治疗癌症的必要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ACS Medicinal Chemistry Letters CHEMISTRY, MEDICINAL-

CiteScore

7.30

自引率

2.40%

发文量

328

审稿时长

1 months

期刊介绍： ACS Medicinal Chemistry Letters is interested in receiving manuscripts that discuss various aspects of medicinal chemistry. The journal will publish studies that pertain to a broad range of subject matter, including compound design and optimization, biological evaluation, drug delivery, imaging agents, and pharmacology of both small and large bioactive molecules. Specific areas include but are not limited to: Identification, synthesis, and optimization of lead biologically active molecules and drugs (small molecules and biologics) Biological characterization of new molecular entities in the context of drug discovery Computational, cheminformatics, and structural studies for the identification or SAR analysis of bioactive molecules, ligands and their targets, etc. Novel and improved methodologies, including radiation biochemistry, with broad application to medicinal chemistry Discovery technologies for biologically active molecules from both synthetic and natural (plant and other) sources Pharmacokinetic/pharmacodynamic studies that address mechanisms underlying drug disposition and response Pharmacogenetic and pharmacogenomic studies used to enhance drug design and the translation of medicinal chemistry into the clinic Mechanistic drug metabolism and regulation of metabolic enzyme gene expression Chemistry patents relevant to the medicinal chemistry field.