Treatment and prevention of recurrent urolithiasis: Insights on molecular mechanism of occurrence and medical care

Arshi Khanam , Gurvirender Singh , Smita Narwal , Balram
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Abstract

Urolithiasis, commonly known as kidney stones, affects a significant portion of the global population. This disease raises the risk of urinary tract infections and kidney failure. According to the WHO study, the anticipated incidence ranges from 1 to 13 percent in different parts of the globe. The recurrence rate of kidney stones is significant. There are effective treatment options, preventative strategies are needed for both new and reoccurring stones to lessen the financial and bodily consequences of urolithiasis. Recent research shows that how common urolithiasis is in both genders changes over time. Males over 35 now have a greater lifetime risk of developing urolithiasis than they did previously. This increased risk is attributed to the influence of sex hormones on urolithiasis. A large majority of scientific and clinical urology research, especially related to renal conditions, concentrates on the diagnosis and treatment of the ailment, with minimal focus on its etiology or recurrence prevention. This study aimed to offer a holistic assessment of the causes and processes of stone formation, metabolic abnormalities, and particularly preventative ways of disease recurrence. This study also advances public understanding of the connection between urolithiasis and dietary, fluid intake, and lifestyle decisions.

复发性尿路结石的治疗和预防:发生的分子机制和医疗护理的启示
泌尿系统结石,俗称肾结石,影响着全球相当一部分人口。这种疾病会增加尿路感染和肾衰竭的风险。根据世卫组织的研究,全球不同地区的预期发病率从 1%到 13%不等。肾结石的复发率很高。虽然有有效的治疗方案,但对于新发和复发的结石都需要采取预防策略,以减轻尿路结石对经济和身体造成的影响。最新研究表明,泌尿系结石在男女两性中的常见程度会随着时间的推移而发生变化。现在,35 岁以上的男性终生罹患尿路结石的风险比以前更高。这种风险的增加归因于性激素对尿路结石的影响。泌尿科的大部分科学和临床研究,尤其是与肾脏疾病有关的研究,都集中在该疾病的诊断和治疗上,而很少关注其病因或复发预防。这项研究旨在全面评估结石形成的原因和过程、代谢异常,尤其是预防疾病复发的方法。这项研究还有助于公众了解泌尿系结石与饮食、液体摄入量和生活方式之间的联系。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Food chemistry advances
Food chemistry advances Analytical Chemistry, Organic Chemistry, Chemistry (General), Molecular Biology
CiteScore
1.90
自引率
0.00%
发文量
0
审稿时长
99 days
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