{"title":"Assessing MC4R Gene Variants and Body Composition in a Heterogenic Population","authors":"Giti Bayhaghi MS, Zubair Karim PhD, Jeane Silva PhD, EdD","doi":"10.1016/j.jneb.2024.05.015","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><p>Obesity is a medical condition assessed by increased body mass index (BMI) and adipose tissue resulting from a complex interaction between genetic and environmental factors. The genes responsible for obesity are related to the leptin axis and the melanocortin pathway, specifically the melanocortin-4 receptor (MC4R) gene. MC4R gene mutations represent the most common monogenic cause of obesity.</p></div><div><h3>Objective</h3><p>Our study aimed to investigate whether mutations in the MC4R gene increase calorie intake, possibly leading to obesity.</p></div><div><h3>Study Design, Settings, Participants</h3><p>We genotyped fifty subjects for common MC4R polymorphisms and subsequently evaluated their anthropometric measurements, daily macronutrient intake, and other pertinent factors.</p></div><div><h3>Results</h3><p>According to our findings, the percentage of genotype carriers (rs34114122, rs61741819, and rs6567166) was higher in the African-American population. In comparison to their Caucasian counterparts, this particular demographic exhibited elevated body fat percentage, body volume, and body density. Conversely, their fat-free mass was observed to be comparatively lower. Furthermore, the African-American population presented with lower thoracic gas. We observed that individuals carrying the genotypes rs34114122, rs61741819, and rs6567166 tended to have higher body fat percentages associated with increased calorie intake.</p></div><div><h3>Conclusions</h3><p>According to our research, the influence of common MC4R variants on obesity and its metabolic disorders might be contingent upon daily dietary intake. Consequently, this could pave the way for individualized dietary regimes to prevent and address obesity and its related comorbidities.</p></div><div><h3>Funding</h3><p>None</p></div>","PeriodicalId":50107,"journal":{"name":"Journal of Nutrition Education and Behavior","volume":"56 8","pages":"Page S5"},"PeriodicalIF":2.3000,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Nutrition Education and Behavior","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1499404624001155","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"EDUCATION, SCIENTIFIC DISCIPLINES","Score":null,"Total":0}
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Abstract
Background
Obesity is a medical condition assessed by increased body mass index (BMI) and adipose tissue resulting from a complex interaction between genetic and environmental factors. The genes responsible for obesity are related to the leptin axis and the melanocortin pathway, specifically the melanocortin-4 receptor (MC4R) gene. MC4R gene mutations represent the most common monogenic cause of obesity.
Objective
Our study aimed to investigate whether mutations in the MC4R gene increase calorie intake, possibly leading to obesity.
Study Design, Settings, Participants
We genotyped fifty subjects for common MC4R polymorphisms and subsequently evaluated their anthropometric measurements, daily macronutrient intake, and other pertinent factors.
Results
According to our findings, the percentage of genotype carriers (rs34114122, rs61741819, and rs6567166) was higher in the African-American population. In comparison to their Caucasian counterparts, this particular demographic exhibited elevated body fat percentage, body volume, and body density. Conversely, their fat-free mass was observed to be comparatively lower. Furthermore, the African-American population presented with lower thoracic gas. We observed that individuals carrying the genotypes rs34114122, rs61741819, and rs6567166 tended to have higher body fat percentages associated with increased calorie intake.
Conclusions
According to our research, the influence of common MC4R variants on obesity and its metabolic disorders might be contingent upon daily dietary intake. Consequently, this could pave the way for individualized dietary regimes to prevent and address obesity and its related comorbidities.
期刊介绍：
The Journal of Nutrition Education and Behavior (JNEB), the official journal of the Society for Nutrition Education and Behavior, is a refereed, scientific periodical that serves as a global resource for all professionals with an interest in nutrition education; nutrition and physical activity behavior theories and intervention outcomes; complementary and alternative medicine related to nutrition behaviors; food environment; food, nutrition, and physical activity communication strategies including technology; nutrition-related economics; food safety education; and scholarship of learning related to these areas.
The purpose of JNEB is to document and disseminate original research and emerging issues and practices relevant to these areas worldwide. The Journal of Nutrition Education and Behavior welcomes evidence-based manuscripts that provide new insights and useful findings related to nutrition education research, practice and policy. The content areas of JNEB reflect the diverse interests in nutrition and physical activity related to public health, nutritional sciences, education, behavioral economics, family and consumer sciences, and eHealth, including the interests of community-based nutrition-practitioners. As the Society''s official journal, JNEB also includes policy statements, issue perspectives, position papers, and member communications.
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