A metal-templated synthesis of precursors for (2S)- and (2R)-2-(3-[18F]fluoropropyl)tyrosines as potential radiotracers for positron emission tomography

IF 1.8 4区化学 Q3 CHEMISTRY, MULTIDISCIPLINARY

Mendeleev Communications Pub Date : 2024-07-01 DOI:10.1016/j.mencom.2024.06.008

Tat’yana F. Savel’yeva, Zalina T. Gugkaeva, Yulia V. Nelyubina, Alexander F. Smol’yakov, Margarita A. Moskalenko, Vladimir A. Larionov, Victor I. Maleev

引用次数: 0

Abstract

New asymmetric metal-templated synthesis of enantiomers of (2S)- and (2R)-2-(3-[¹⁹F]fluoropropyl)tyrosine precursors were obtained based on a chiral Ni^II complex of the Schiff base derived from (S)-2-[N-(N’-benzylprolyl)amino]-benzaldehyde and racemic tyrosine in five steps. The free tyrosine derivatives which can be obtained upon decomplexation seem promising radiotracers for positron emission tomography imaging provided the introduction of ¹⁸F isotope.

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(2S)-和(2R)-2-(3-[18F]氟丙基)酪氨酸作为正电子发射断层扫描潜在放射性示踪剂前体的金属催化合成方法

基于(S)-2-[N-(N'-苄基丙基)氨基]-苯甲醛和外消旋酪氨酸衍生的希夫碱的手性 NiII 复合物，通过五个步骤获得了(2S)-和(2R)-2-(3-[19F]氟丙基)酪氨酸对映体的新的不对称金属催化合成。在引入 18F 同位素的情况下，解络合后得到的游离酪氨酸衍生物似乎很有希望成为正电子发射断层成像的放射性痕量物质。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Mendeleev Communications 化学-化学综合

CiteScore

3.00

自引率

21.10%

发文量

226

审稿时长

4-8 weeks

期刊介绍： Mendeleev Communications is the journal of the Russian Academy of Sciences, launched jointly by the Academy of Sciences of the USSR and the Royal Society of Chemistry (United Kingdom) in 1991. Starting from 1st January 2007, Elsevier is the new publishing partner of Mendeleev Communications. Mendeleev Communications publishes short communications in chemistry. The journal primarily features papers from the Russian Federation and the other states of the former USSR. However, it also includes papers by authors from other parts of the world. Mendeleev Communications is not a translated journal, but instead is published directly in English. The International Editorial Board is composed of eminent scientists who provide advice on refereeing policy.