Visual contrast sensitivity is associated with community structure integrity in cognitively unimpaired older adults: the Brain Networks and Mobility (B-NET) Study

IF 1.7 Q3 CLINICAL NEUROLOGY
Alexis D. Tanase , Haiying Chen , Michael E. Miller , Christina E. Hugenschmidt , Jeff D. Williamson , Stephen B. Kritchevsky , Paul J. Laurienti , Atalie C. Thompson
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Abstract

Older adults with impairment in contrast sensitivity (CS), the ability to visually perceive differences in light and dark, are more likely to demonstrate limitations in mobility function, but the mechanisms underlying this relationship are poorly understood. We sought to determine if functional brain networks important to visual processing and mobility may help elucidate possible neural correlates of this relationship. This cross-sectional analysis utilized functional MRI both at rest and during a motor imagery (MI) task in 192 community-dwelling, cognitively-unimpaired older adults 70 years of age from the Brain Networks and Mobility study (B-NET). Brain networks were partitioned into network communities, groups of regions that are more interconnected with each other than the rest of the brain, the spatial consistency of the communities for multiple brain subnetworks was assessed. Lower baseline binocular CS was significantly associated with degraded sensorimotor network (SMN) community structure at rest. During the MI task, lower binocular CS was significantly associated with degraded community structure in both the visual (VN) and default mode network (DMN). These findings may suggest shared neural pathways for visual and mobility dysfunction that could be targeted in future studies.

视觉对比敏感度与认知能力未受损的老年人群落结构完整性相关:脑网络与移动性(B-NET)研究
对比敏感度(CS)是视觉感知明暗差异的能力,对比敏感度受损的老年人更有可能表现出行动功能的限制,但人们对这种关系的内在机制却知之甚少。我们试图确定对视觉处理和行动能力有重要影响的大脑功能网络是否有助于阐明这种关系的可能神经相关性。这项横断面分析采用了功能性核磁共振成像技术,研究对象是脑网络和行动能力研究(B-NET)中 192 名居住在社区、认知能力未受损且年龄≥ 70 岁的老年人,研究对象在静息状态和执行运动想象(MI)任务时都进行了核磁共振成像。大脑网络被划分为网络群落,即比大脑其他部分相互联系更紧密的区域群落,并对多个大脑子网络群落的空间一致性进行了评估。在静息状态下,较低的基线双眼CS与退化的感觉运动网络(SMN)群落结构显著相关。在进行多重刺激任务时,较低的双目CS与视觉网络(VN)和默认模式网络(DMN)中退化的群落结构明显相关。这些发现可能暗示了视觉和运动功能障碍的共同神经通路,可作为未来研究的目标。
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来源期刊
Aging brain
Aging brain Neuroscience (General), Geriatrics and Gerontology
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