Triple Nanosystems Based on Amphiphilic Molecular Brushes, Selenium Nanoparticles and Photosensitizer: Synthesis, Spectral, and Morphological Characteristics

IF 0.8 Q3 Engineering

Nanotechnologies in Russia Pub Date : 2024-08-06 DOI:10.1134/S2635167623601250

S. V. Valueva, E. L. Krasnopeeva, L. N. Borovikova, P. Yu. Morozova, M. P. Sokolova, E. Yu. Melenevskaya, A. V. Yakimansky

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引用次数: 0

Abstract

In order to create new high efficient anticancer drugs for photodynamic therapy (PDT) the triple complexes on the basis of the zero-valent selenium (Se⁰) nanoparticles, graft copolymer (Cell-graft-PMAA) and photosensitizer-fotoditazin (FD) with various priority of introduction of the components have been synthesized and studied. The comparative studies of the spectral and morphological characteristics of the triple complexes (Cell-graft-PMAA/SeNPs) (the 1st method) and (Cell-graft-PMAA/FD/SeNPs) (the 2nd method) with the similar characteristics of FD and double complexes of the variable composition (SeNPs/Cell-graft-PMAA, SeNPs/FD and Cell-graft-PMAA/FD) were carried out by means of UV/IR spectroscopy, luminescence and atomic force microscopy. By means of the UV spectroscopy it was demonstrated that the value of the optical density in the range of PDT wavelength (Q-range) is higher in the triple systems by 30–40% compared to free FD and luminescence intensity in the Q-range for these nanosystems is in excess of 6 times compared to the intensity for FD.

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基于两性分子刷、硒纳米粒子和光敏剂的三重纳米系统：合成、光谱和形态特征

摘要为了制备新型高效光动力疗法（PDT）抗癌药物，我们合成并研究了以零价硒（Se0）纳米粒子、接枝共聚物（Cell-graft-PMAA）和光敏剂-磷哒嗪（FD）为基础的三重复合物，其中各组分的引入具有不同的优先级。通过紫外/红外光谱、发光和原子力显微镜，比较研究了三重复合物（Cell-graft-PMAA/SeNPs）（第一种方法）和（Cell-graft-PMAA/FD/SeNPs）（第二种方法）的光谱和形态特征，以及与 FD 相似的特征和不同组成的双重复合物（SeNPs/Cell-graft-PMAA、SeNPs/FD 和 Cell-graft-PMAA/FD）。紫外光谱显示，与游离 FD 相比，三重系统在 PDT 波长范围（Q-range）内的光密度值要高出 30-40%；与 FD 相比，这些纳米系统在 Q 范围内的发光强度超过 6 倍。

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来源期刊

Nanotechnologies in Russia NANOSCIENCE & NANOTECHNOLOGY-

CiteScore

1.20

自引率

0.00%

发文量

期刊介绍： Nanobiotechnology Reports publishes interdisciplinary research articles on fundamental aspects of the structure and properties of nanoscale objects and nanomaterials, polymeric and bioorganic molecules, and supramolecular and biohybrid complexes, as well as articles that discuss technologies for their preparation and processing, and practical implementation of products, devices, and nature-like systems based on them. The journal publishes original articles and reviews that meet the highest scientific quality standards in the following areas of science and technology studies: self-organizing structures and nanoassemblies; nanostructures, including nanotubes; functional and structural nanomaterials; polymeric, bioorganic, and hybrid nanomaterials; devices and products based on nanomaterials and nanotechnology; nanobiology and genetics, and omics technologies; nanobiomedicine and nanopharmaceutics; nanoelectronics and neuromorphic computing systems; neurocognitive systems and technologies; nanophotonics; natural science methods in a study of cultural heritage items; metrology, standardization, and monitoring in nanotechnology.