Preparation of a starch derivative bearing chloroaniline groups and the evaluation of its hemolytic, cytotoxic and antibacterial activities

IF 2.9 4区化学 Q2 POLYMER SCIENCE

Polymer International Pub Date : 2024-08-06 DOI:10.1002/pi.6689

María Fernanda Valdez‐Valdés, Francisco Javier Enríquez‐Medrano, Alejandro Zugasti‐Cruz, Crystel Aleyvick Sierra‐Rivera, Eder Iván Martínez‐Mora, Gerardo de Jesús Sosa‐Santillán, Ernesto Oyervides‐Muñoz

{"title":"Preparation of a starch derivative bearing chloroaniline groups and the evaluation of its hemolytic, cytotoxic and antibacterial activities","authors":"María Fernanda Valdez‐Valdés, Francisco Javier Enríquez‐Medrano, Alejandro Zugasti‐Cruz, Crystel Aleyvick Sierra‐Rivera, Eder Iván Martínez‐Mora, Gerardo de Jesús Sosa‐Santillán, Ernesto Oyervides‐Muñoz","doi":"10.1002/pi.6689","DOIUrl":null,"url":null,"abstract":"A new starch derivative with antibacterial properties and non‐hemolytic effect was synthesized through the chemical grafting of 4‐chloroaniline onto the backbone of potato starch. In a first step, starch was extracted from potatoes grown in the region of Coahuila, Mexico, using the water steeping method. The hydroxyl groups (C5‐C6) of the native starch were oxidized using sodium periodate. The resulting dialdehyde was then chemically modified through a Schiff base reaction with 4‐chloroaniline. The chemical structure of this starch derivative was confirmed by Fourier transform infrared and 1H NMR spectroscopies, the thermal properties were analyzed by thermogravimetric analysis without finding significant changes and the product showed antibacterial activity against Gram‐negative E. coli and Gram‐positive S. aureus strains. Finally, the hemolytic and cytotoxic effects of native starch and its derivative were studied, showing no hemolytic effect on isolated human red blood cells and no cytotoxic effect; therefore, it can be considered biocompatible. © 2024 Society of Chemical Industry.","PeriodicalId":20404,"journal":{"name":"Polymer International","volume":"1 1","pages":""},"PeriodicalIF":2.9000,"publicationDate":"2024-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Polymer International","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1002/pi.6689","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"POLYMER SCIENCE","Score":null,"Total":0}

引用次数: 0

Abstract

A new starch derivative with antibacterial properties and non‐hemolytic effect was synthesized through the chemical grafting of 4‐chloroaniline onto the backbone of potato starch. In a first step, starch was extracted from potatoes grown in the region of Coahuila, Mexico, using the water steeping method. The hydroxyl groups (C5‐C6) of the native starch were oxidized using sodium periodate. The resulting dialdehyde was then chemically modified through a Schiff base reaction with 4‐chloroaniline. The chemical structure of this starch derivative was confirmed by Fourier transform infrared and 1H NMR spectroscopies, the thermal properties were analyzed by thermogravimetric analysis without finding significant changes and the product showed antibacterial activity against Gram‐negative E. coli and Gram‐positive S. aureus strains. Finally, the hemolytic and cytotoxic effects of native starch and its derivative were studied, showing no hemolytic effect on isolated human red blood cells and no cytotoxic effect; therefore, it can be considered biocompatible. © 2024 Society of Chemical Industry.

查看原文本刊更多论文

含氯苯胺基团的淀粉衍生物的制备及其溶血、细胞毒性和抗菌活性的评估

通过化学方法将 4-氯苯胺接枝到马铃薯淀粉的骨架上，合成了一种具有抗菌特性和非溶血性作用的新型淀粉衍生物。第一步，采用水浸法从墨西哥科阿韦拉地区种植的马铃薯中提取淀粉。原生淀粉的羟基（C5-C6）被高碘酸钠氧化。然后通过与 4-氯苯胺的希夫碱反应对生成的二醛进行化学修饰。傅立叶变换红外光谱和 1H NMR 光谱证实了这种淀粉衍生物的化学结构，热重分析对其热性质进行了分析，未发现明显变化，而且该产品对革兰氏阴性大肠杆菌和革兰氏阳性金黄色葡萄球菌菌株具有抗菌活性。最后，研究了原生淀粉及其衍生物的溶血效应和细胞毒性效应，结果表明其对离体人红细胞无溶血效应，也无细胞毒性效应，因此可视为具有生物相容性。© 2024 化学工业协会。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Polymer International 化学-高分子科学

CiteScore

7.10

自引率

3.10%

发文量

135

审稿时长

4.3 months

期刊介绍： Polymer International (PI) publishes the most significant advances in macromolecular science and technology. PI especially welcomes research papers that address applications that fall within the broad headings Energy and Electronics, Biomedical Studies, and Water, Environment and Sustainability. The Journal’s editors have identified these as the major challenges facing polymer scientists worldwide. The Journal also publishes invited Review, Mini-review and Perspective papers that address these challenges and others that may be of growing or future relevance to polymer scientists and engineers.