{"title":"Study on hemostatic and antibacterial properties of modified silicone rubber sponge","authors":"","doi":"10.1016/j.reactfunctpolym.2024.106020","DOIUrl":null,"url":null,"abstract":"<div><p>At present, gauze compression and hemostatic powder are commonly used in first aid to stop bleeding. However, the hemostatic effect of gauze compression is poor, and the hemostatic powder is easy to block blood vessels and causes thrombosis. Therefore, developing hemostatic materials with rapid hemostatic function and biosafety remains a challenge. In this article, a double layer hemostatic dressing based on silicone rubber (SR) was prepared. Among them, sponge layer was modified with polydopamine (PDA), and connected to the hydrophilic polymer polyvinylpyrrolidone (PVP) by strong hydrogen bonding. The synergistic synergy of the blood cell affinity of the catechol group and the water absorption of sponge enhanced the hemostatic ability. For the SR layer, ZnO was grown in situ by hydrothermal method as an antimicrobial layer (SRZ). SRZ/PDA-PVP dressing has good mechanical properties, antibacterial properties, coagulation ability and excellent biocompatibility, providing a new idea for the development of hemostatic materials.</p></div>","PeriodicalId":20916,"journal":{"name":"Reactive & Functional Polymers","volume":null,"pages":null},"PeriodicalIF":4.5000,"publicationDate":"2024-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Reactive & Functional Polymers","FirstCategoryId":"5","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1381514824001950","RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, APPLIED","Score":null,"Total":0}
引用次数: 0
Abstract
At present, gauze compression and hemostatic powder are commonly used in first aid to stop bleeding. However, the hemostatic effect of gauze compression is poor, and the hemostatic powder is easy to block blood vessels and causes thrombosis. Therefore, developing hemostatic materials with rapid hemostatic function and biosafety remains a challenge. In this article, a double layer hemostatic dressing based on silicone rubber (SR) was prepared. Among them, sponge layer was modified with polydopamine (PDA), and connected to the hydrophilic polymer polyvinylpyrrolidone (PVP) by strong hydrogen bonding. The synergistic synergy of the blood cell affinity of the catechol group and the water absorption of sponge enhanced the hemostatic ability. For the SR layer, ZnO was grown in situ by hydrothermal method as an antimicrobial layer (SRZ). SRZ/PDA-PVP dressing has good mechanical properties, antibacterial properties, coagulation ability and excellent biocompatibility, providing a new idea for the development of hemostatic materials.
目前，急救中常用纱布压迫和止血粉止血。但纱布压迫止血效果差，止血粉易堵塞血管，导致血栓形成。因此，开发具有快速止血功能和生物安全性的止血材料仍是一项挑战。本文制备了一种基于硅橡胶（SR）的双层止血敷料。其中，海绵层采用聚多巴胺（PDA）改性，并与亲水性聚合物聚乙烯吡咯烷酮（PVP）通过强氢键连接。儿茶酚基团的血细胞亲和力与海绵的吸水性协同增效，增强了止血能力。至于 SR 层，则采用水热法原位生长氧化锌作为抗菌层（SRZ）。SRZ/PDA-PVP 敷料具有良好的机械性能、抗菌性能、凝血能力和优异的生物相容性，为止血材料的开发提供了新思路。
期刊介绍：
Reactive & Functional Polymers provides a forum to disseminate original ideas, concepts and developments in the science and technology of polymers with functional groups, which impart specific chemical reactivity or physical, chemical, structural, biological, and pharmacological functionality. The scope covers organic polymers, acting for instance as reagents, catalysts, templates, ion-exchangers, selective sorbents, chelating or antimicrobial agents, drug carriers, sensors, membranes, and hydrogels. This also includes reactive cross-linkable prepolymers and high-performance thermosetting polymers, natural or degradable polymers, conducting polymers, and porous polymers.
Original research articles must contain thorough molecular and material characterization data on synthesis of the above polymers in combination with their applications. Applications include but are not limited to catalysis, water or effluent treatment, separations and recovery, electronics and information storage, energy conversion, encapsulation, or adhesion.
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