Sesquiterpenes from Tinospora sinensis and their chemotaxonomic significance

IF 1.4 4区生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biochemical Systematics and Ecology Pub Date : 2024-08-08 DOI:10.1016/j.bse.2024.104877

引用次数: 0

Abstract

Chemical investigation of the Tinospora sinensis led to the isolation of a new cadinane sesquiterpene (1) and twelve known sesquiterpenes (2−13). The structures of these compounds were deduced using a suite of comprehensive spectroscopic techniques including NMR, MS etc., and the absolute configuration of 1 was established through a combination of TDDFT calculations and chemical methods. Compound 1 demonstrated mild cytotoxicity against MDA-MB-231 cell line, with an inhibition rate of 46.8% and 54.2% at 50 μmol/L and 100 μmol/L, respectively. Compounds 1, 5−13 were reported to exist in the Menispermaceae family for the first time. Furthermore, the chemotaxonomic significance of the isolates is also discussed.

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虎耳草中的半萜及其化学分类学意义

通过对这些化合物的化学研究，分离出了一种新的卡迪烷倍半萜（）和十二种已知的倍半萜（-）。这些化合物的结构是利用包括核磁共振、质谱在内的一整套综合光谱技术推导出来的，其绝对构型是通过 TDDFT 计算和化学方法相结合确定的。化合物对 MDA-MB-231 细胞株具有温和的细胞毒性，在 50 μmol/L 和 100 μmol/L 浓度下的抑制率分别为 46.8% 和 54.2%。首次报道了 Menispermaceae 家族中存在Ⅳ-化合物。此外，还讨论了分离物的化学分类学意义。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biochemical Systematics and Ecology 生物-进化生物学

CiteScore

3.00

自引率

12.50%

发文量

147

审稿时长

43 days

期刊介绍： Biochemical Systematics and Ecology is devoted to the publication of original papers and reviews, both submitted and invited, in two subject areas: I) the application of biochemistry to problems relating to systematic biology of organisms (biochemical systematics); II) the role of biochemistry in interactions between organisms or between an organism and its environment (biochemical ecology). In the Biochemical Systematics subject area, comparative studies of the distribution of (secondary) metabolites within a wider taxon (e.g. genus or family) are welcome. Comparative studies, encompassing multiple accessions of each of the taxa within their distribution are particularly encouraged. Welcome are also studies combining classical chemosystematic studies (such as comparative HPLC-MS or GC-MS investigations) with (macro-) molecular phylogenetic studies. Studies that involve the comparative use of compounds to help differentiate among species such as adulterants or substitutes that illustrate the applied use of chemosystematics are welcome. In contrast, studies solely employing macromolecular phylogenetic techniques (gene sequences, RAPD studies etc.) will be considered out of scope. Discouraged are manuscripts that report known or new compounds from a single source taxon without addressing a systematic hypothesis. Also considered out of scope are studies using outdated and hard to reproduce macromolecular techniques such as RAPDs in combination with standard chemosystematic techniques such as GC-FID and GC-MS.